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帕米膦酸诱导慢性非细菌性骨髓炎临床缓解与Vγ9Vδ2 T细胞受体表达降低有关。

Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression.

作者信息

Watson Lily, V Ramanan Athimalaipet, Oliver Elizabeth, Segers Francisca, Jones Gareth W, Chew Christine, Goenka Anu

机构信息

Bristol Medical School, University of Bristol, Bristol, UK.

Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.

出版信息

Eur J Immunol. 2025 Apr;55(4):e202451609. doi: 10.1002/eji.202451609.

DOI:10.1002/eji.202451609
PMID:40257409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12010949/
Abstract

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

摘要

在患有慢性非细菌性骨髓炎的儿童中，对帕米膦酸盐治疗后的外周血进行了临床和转录变化检测。帕米膦酸盐的临床有效治疗与编码Vγ9Vδ2 T细胞受体亚基的两个基因（TRDV2和TRGV9）的表达降低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f8d/12010949/e50f5daf90ed/EJI-55-e202451609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f8d/12010949/e50f5daf90ed/EJI-55-e202451609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f8d/12010949/e50f5daf90ed/EJI-55-e202451609-g001.jpg

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本文引用的文献

1
Incidence of chronic recurrent multifocal osteomyelitis in children and adolescents in the UK and Republic of Ireland.英国和爱尔兰共和国儿童及青少年慢性复发性多灶性骨髓炎的发病率。
Rheumatology (Oxford). 2025 Apr 1;64(4):2162-2170. doi: 10.1093/rheumatology/keae447.
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Phosphoantigen recognition by Vγ9Vδ2 T cells.磷酸抗原的 Vγ9Vδ2 T 细胞识别。
Eur J Immunol. 2024 Nov;54(11):e2451068. doi: 10.1002/eji.202451068. Epub 2024 Aug 15.
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γδ T cells: origin and fate, subsets, diseases and immunotherapy.γδ T 细胞：起源与命运、亚群、疾病与免疫治疗。
Signal Transduct Target Ther. 2023 Nov 22;8(1):434. doi: 10.1038/s41392-023-01653-8.
4
Priorities in Chronic nonbacterial osteomyelitis (CNO) - results from an international survey and roundtable discussions.慢性非细菌性骨髓炎（CNO）的优先事项 - 来自国际调查和圆桌讨论的结果。
Pediatr Rheumatol Online J. 2023 Jun 30;21(1):65. doi: 10.1186/s12969-023-00851-6.
5
TNF-inhibitors or bisphosphonates in chronic nonbacterial osteomyelitis? - Results of an international retrospective multicenter study.慢性非细菌性骨髓炎中使用肿瘤坏死因子抑制剂还是双膦酸盐？——一项国际回顾性多中心研究结果
Clin Immunol. 2022 May;238:109018. doi: 10.1016/j.clim.2022.109018. Epub 2022 Apr 20.
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Bisphosphonates in inflammatory rheumatic diseases.二膦酸盐类药物在炎症性风湿性疾病中的应用。
Bone. 2021 May;146:115887. doi: 10.1016/j.bone.2021.115887. Epub 2021 Feb 14.
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The jigsaw puzzle of chronic non-bacterial osteomyelitis: are anti-IL17 therapies the next piece?慢性非细菌性骨髓炎的拼图：抗IL17疗法会是下一块拼图吗？
Rheumatology (Oxford). 2020 Mar 1;59(3):459-461. doi: 10.1093/rheumatology/kez492.
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Pediatr Rheumatol Online J. 2019 Jul 18;17(1):45. doi: 10.1186/s12969-019-0351-4.
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