帕米膦酸诱导慢性非细菌性骨髓炎临床缓解与Vγ9Vδ2 T细胞受体表达降低有关。
Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression.
作者信息
Watson Lily, V Ramanan Athimalaipet, Oliver Elizabeth, Segers Francisca, Jones Gareth W, Chew Christine, Goenka Anu
机构信息
Bristol Medical School, University of Bristol, Bristol, UK.
Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.
出版信息
Eur J Immunol. 2025 Apr;55(4):e202451609. doi: 10.1002/eji.202451609.
Abstract
In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.
摘要
在患有慢性非细菌性骨髓炎的儿童中，对帕米膦酸盐治疗后的外周血进行了临床和转录变化检测。帕米膦酸盐的临床有效治疗与编码Vγ9Vδ2 T细胞受体亚基的两个基因（TRDV2和TRGV9）的表达降低有关。
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