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在法洛四联症合并肺动脉狭窄的分期修复中,动脉导管支架在姑息治疗方面与外科分流术的效果一样吗?

Is arterial ductal stent as effective as surgical shunt for palliation in staged repair of tetralogy of Fallot with pulmonary stenosis?

作者信息

Ho Yan Le, Haranal Maruti, Che Mood Marhisham, Ajik Esther Mathias, Basran Nurul Fazira, Alwi Mazeni, Sivalingam Sivakumar

机构信息

Department of Cardiothoracic and Vascular Surgery, National Heart Institute, Kuala Lumpur, Malaysia.

Department of Paediatric Cardiac Surgery, UN Mehta Institute of Cardiology and Research, Ahmedabad, India.

出版信息

Interdiscip Cardiovasc Thorac Surg. 2025 Jun 4;40(6). doi: 10.1093/icvts/ivaf088.

Abstract

INTRODUCTION

A staged repair strategy in the form of Modified Blalock-Taussig-Thomas shunt has been performed to facilitate the growth of pulmonary valve annulus, so that patients with marginally small annulus could benefit from pulmonary valve-sparing repair. However, little has been reported on the influence of arterial ductal stent (ADS) on the growth of pulmonary annulus and pulmonary artery, with subsequent valve-sparing repair.

METHODS

Patients who underwent staged repair of tetralogy of Fallot with Pulmonary Stenosis with either ADS or surgical shunt were included. Echocardiographic and angiographic measurements of pulmonary annulus and pulmonary artery prior to initial palliation and complete repair were recorded.

RESULTS

A total of 110 patients were included, 44 (40%) patients underwent ADS and 66 (60%) patients had surgical shunt. Pulmonary annulus and pulmonary arteries grew significantly following palliation with both ADS (P = 0.011) and surgical shunt (P < 0.01), with a similar rate of increment (P = 0.205). There was no significant difference in the rate of valve-sparing repair between the 2 groups (MBTTS, 62.1% vs ADS, 47.7%, P = 0.149). However, patients who underwent ADS had shorter stays in hospital (P = 0.048). Reintervention rate and mortality rate in the interstage period were similar in both groups (P = 0.229 and P = 0.210, respectively). There was no reintervention in patients who successfully underwent valve-sparing repair following both palliation groups in the follow-up period.

CONCLUSIONS

ADS is as effective as surgical shunt as a palliative procedure in promoting the growth of pulmonary annulus and pulmonary arteries, with comparable rate of valve-sparing repair during corrective surgery.

摘要

引言

已采用改良布莱洛克 - 陶西格 - 托马斯分流术形式的分期修复策略来促进肺动脉瓣环生长,以使瓣环略小的患者能从保留肺动脉瓣的修复中获益。然而,关于动脉导管支架(ADS)对肺动脉瓣环和肺动脉生长以及后续保留瓣膜修复的影响,鲜有报道。

方法

纳入接受法洛四联症合并肺动脉狭窄分期修复且采用ADS或外科分流术的患者。记录初始姑息治疗和完全修复前肺动脉瓣环和肺动脉的超声心动图及血管造影测量值。

结果

共纳入110例患者,44例(40%)患者接受ADS,66例(60%)患者接受外科分流术。采用ADS(P = 0.011)和外科分流术(P < 0.01)进行姑息治疗后,肺动脉瓣环和肺动脉均显著生长,生长速率相似(P = 0.205)。两组间保留瓣膜修复率无显著差异(改良布莱洛克 - 陶西格分流术为62.1%,ADS为47.7%,P = 0.149)。然而,接受ADS的患者住院时间较短(P = 0.048)。两组间过渡期再次干预率和死亡率相似(分别为P = 0.229和P = 0.210)。在随访期,两组姑息治疗后成功接受保留瓣膜修复的患者均未再次干预。

结论

作为一种姑息治疗方法,ADS在促进肺动脉瓣环和肺动脉生长方面与外科分流术同样有效,在矫正手术期间保留瓣膜修复率相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50b/12148213/5a0f51f2b97c/ivaf088f4.jpg

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