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改良布莱洛克-陶西格分流术:当代法洛四联症中的临床影响及发病率

The modified Blalock-Taussig shunt: clinical impact and morbidity in Fallot's tetralogy in the current era.

作者信息

Gladman G, McCrindle B W, Williams W G, Freedom R M, Benson L N

机构信息

Department of Pediatrics, Hospital for Sick Children, University of Toronto School of Medicine, Ontario, Canada.

出版信息

J Thorac Cardiovasc Surg. 1997 Jul;114(1):25-30. doi: 10.1016/S0022-5223(97)70113-2.

Abstract

BACKGROUND

The Blalock-Taussig shunt is considered a low-risk management option for palliation in tetralogy of Fallot, but the morbidity associated with a Blalock-Taussig shunt can have a significant impact on patient care. We reviewed the outcome for this operation in the current era.

METHODS

Between 1990 and 1994, 65 children with tetralogy of Fallot received a modified Blalock-Taussig shunt. Sixty patients who had follow-up angiography were assessed for clinical outcomes and shunt-related morbidity and mortality. From the same study period, 68 of 247 pediatric patients who underwent angiography and tetralogy repair, but did not receive palliation, were randomly selected to comprise a comparison group.

RESULTS

Palliation was more likely in the presence of a complicated tetralogy malformation or if there was an associated medical condition. Median age at palliation was 58 days (range: 1 to 535 days). Ninety-five percent of shunts were right-sided. Self-limited morbidity complicated 11% of shunt operations. Significantly smaller distal right pulmonary arteries were observed in the palliated group before total repair compared with findings in the group without palliation and 33% of patients who underwent palliation had angiographic evidence of pulmonary artery distortion. Shunt stenosis was common and correlated with younger age at palliation. Shunt occlusion resulted in one death. Excluding noncardiac causes of death, overall survival was 90% in the palliated group versus 97% in the nonpalliated group (p = 0.09).

CONCLUSIONS

Pulmonary artery hypoplasia and angiographic evidence of pulmonary artery distortion are common after initial palliation by a modified Blalock-Taussig shunt. Neonatal palliation was associated with significantly smaller pulmonary arteries before repair, which necessitated additional interventions.

摘要

背景

布-塔分流术被认为是法洛四联症姑息治疗的低风险管理选择,但布-塔分流术相关的发病率可能对患者护理产生重大影响。我们回顾了当前时代该手术的结果。

方法

1990年至1994年期间,65例法洛四联症患儿接受了改良布-塔分流术。对60例接受随访血管造影的患者进行了临床结局以及分流相关发病率和死亡率的评估。从同一研究期间,随机选择247例接受血管造影和法洛四联症修复但未接受姑息治疗的儿科患者中的68例组成对照组。

结果

在存在复杂的四联症畸形或伴有相关内科疾病的情况下,更有可能进行姑息治疗。姑息治疗时的中位年龄为58天(范围:1至535天)。95%的分流是右侧的。11%的分流手术出现自限性发病。与未接受姑息治疗的组相比,姑息治疗组在完全修复前观察到远端右肺动脉明显更小,并且33%接受姑息治疗的患者有肺动脉扭曲的血管造影证据。分流狭窄很常见,且与姑息治疗时年龄较小相关。分流闭塞导致1例死亡。排除非心脏原因导致的死亡,姑息治疗组的总体生存率为90%,未接受姑息治疗组为97%(p = 0.09)。

结论

改良布-塔分流术初次姑息治疗后,肺动脉发育不全和肺动脉扭曲的血管造影证据很常见。新生儿姑息治疗与修复前肺动脉明显更小相关,这需要额外的干预措施。

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