研讨会报告——异质性与成功老龄化 第二部分：衰老研究中调查异质性的方法
Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research.
作者信息
Kumar Vivek, Hevener Andrea L, Ruby J Graham, Sebastiani Paola, Kuchel George A
机构信息
The Jackson Laboratory, Bar Harbor, Maine, USA.
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2025 Apr 7;80(5). doi: 10.1093/gerona/glaf021.
Abstract
Heterogeneity in aging is a fundamental biological process arising from multifactorial etiologies, including genetic, lifestyle, and socioeconomic factors. Modeling this heterogeneity in animal systems is critical for elucidating the underlying mechanisms of aging and for leveraging these insights in translational research. Here we present part II, a summary of the model organism research presented at the NIA Heterogeneity and Successful Aging workshop, held in May 2023.
摘要
衰老的异质性是一个由多因素病因引起的基本生物学过程，这些病因包括遗传、生活方式和社会经济因素。在动物系统中对这种异质性进行建模，对于阐明衰老的潜在机制以及在转化研究中利用这些见解至关重要。在此，我们呈现第二部分，这是对2023年5月举行的美国国立衰老研究所（NIA）异质性与成功衰老研讨会上所展示的模式生物研究的总结。
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