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Glucagon-like-peptide 1 receptor agonist for metabolic dysfunction-associated steatotic liver disease: hype or hope?

作者信息

Wong Yu Jun, Goh George Boon-Bee

机构信息

Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.

Duke-NUS Medical School, Singapore.

出版信息

Singapore Med J. 2025 Apr 1;66(4):173-174. doi: 10.4103/singaporemedj.SMJ-2025-051. Epub 2025 Apr 22.

DOI:10.4103/singaporemedj.SMJ-2025-051
PMID:40258233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12063942/
Abstract
摘要

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本文引用的文献

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The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease.亚太肝脏研究协会代谢功能障碍相关脂肪性肝病诊断和管理临床实践指南
Hepatol Int. 2025 Apr;19(2):261-301. doi: 10.1007/s12072-024-10774-3. Epub 2025 Feb 27.
2
Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021.2010年至2021年代谢功能障碍相关脂肪性肝病的全球负担
JHEP Rep. 2024 Nov 14;7(3):101271. doi: 10.1016/j.jhepr.2024.101271. eCollection 2025 Mar.
3
Comparison of pharmacological therapies in metabolic dysfunction-associated steatohepatitis for fibrosis regression and MASH resolution: Systematic review and network meta-analysis.代谢功能障碍相关脂肪性肝炎中用于纤维化消退和MASH缓解的药物治疗比较：系统评价和网状Meta分析
Hepatology. 2025 Feb 4. doi: 10.1097/HEP.0000000000001254.
4
GLP-1 Receptor Agonists and Risk for Cirrhosis and Related Complications in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.GLP-1 受体激动剂与代谢相关脂肪性肝病合并非酒精性脂肪性肝病患者发生肝硬化及相关并发症的风险
JAMA Intern Med. 2024 Nov 1;184(11):1314-1323. doi: 10.1001/jamainternmed.2024.4661.
5
Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis.替尔泊肽治疗代谢相关脂肪性肝炎伴肝纤维化
N Engl J Med. 2024 Jul 25;391(4):299-310. doi: 10.1056/NEJMoa2401943. Epub 2024 Jun 8.
6
A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis.MASH 和纤维化中苏沃杜肽的 2 期随机试验。
N Engl J Med. 2024 Jul 25;391(4):311-319. doi: 10.1056/NEJMoa2401755. Epub 2024 Jun 7.
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