Liu Huan, Wang Lei, Zhou Jinhua
Department of Emergency Internal Medicine, Jining NO.1 People's Hospital, Jining, PR China.
Department of Pulmonary and Critical Care Medicine, Jining NO.1 People's Hospital, Jining, PR China.
Medicine (Baltimore). 2025 Apr 18;104(16):e42132. doi: 10.1097/MD.0000000000042132.
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host immune response to infection. It is associated with a high incidence, intricate pathophysiological mechanisms, and rapidly progressive severity, rendering it a leading cause of mortality among patients in intensive care units. The Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a transcription factor pivotal for maintaining cellular redox homeostasis by regulating the expression of antioxidant and cytoprotective genes. Emerging evidence suggests that activation of the Nrf2 signaling pathway attenuates sepsis-induced inflammatory responses, oxidative stress, and organ dysfunction, thereby improving clinical outcomes. These findings underscore the potential of Nrf2 as a therapeutic target, offering a promising avenue for the development of novel interventions aimed at mitigating the complications and improving the prognosis of sepsis.
脓毒症是一种危及生命的病症，其特征是宿主对感染的免疫反应失调导致器官功能障碍。它与高发病率、复杂的病理生理机制以及迅速进展的严重程度相关，使其成为重症监护病房患者死亡的主要原因。核因子红细胞2相关因子2（Nrf2）是一种转录因子，通过调节抗氧化和细胞保护基因的表达对维持细胞氧化还原稳态至关重要。新出现的证据表明，Nrf2信号通路的激活可减轻脓毒症诱导的炎症反应、氧化应激和器官功能障碍，从而改善临床结局。这些发现强调了Nrf2作为治疗靶点的潜力，为开发旨在减轻脓毒症并发症和改善预后的新型干预措施提供了一条有前景的途径。
