Önal Hülya Gözde, Önal Mesut, Nalçacioğlu Hülya, Tekcan Karali Demet
Department of Pediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Gynecology and Obstetrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Medicine (Baltimore). 2025 Apr 18;104(16):e42159. doi: 10.1097/MD.0000000000042159.
Chronic kidney disease (CKD) is associated with growth retardation and delayed pubertal development in the pediatric population. This study aimed to investigate the impact of CKD on growth and pubertal development in children and adolescents by considering factors such as dialysis and transplantation. A cross-sectional retrospective study was conducted in a cohort of 52 pediatric patients aged 0 to 18; the patients had been diagnosed with stages 2 to 5 CKD and were undergoing dialysis treatment or kidney transplantation. Demographic information, clinical characteristics, pubertal development, and treatment methods were also collected. The relationships between these factors and pubertal development were also analyzed. This study revealed significant delays in growth and pubertal development in children and adolescents with CKD. The mean age at menarche was 12.79, and 32.8% of the patients had primary amenorrhea. Patients on dialysis and those who underwent transplantation displayed further growth and pubertal outcomes. Factors such as the CKD stage (r = 0.35; P = .02) and age at diagnosis (r = -0.28; P = .01) significantly influenced the relationship between CKD and pubertal development. The results of this study were associated with delayed pubertal growth in this population. Our findings underscore the significant impact of CKD on the growth and pubertal development of children and adolescents. The early detection, intervention, and comprehensive management of CKD and its complications could aid in improving growth and pubertal outcomes in this vulnerable population.
慢性肾脏病（CKD）与儿科人群的生长发育迟缓及青春期发育延迟有关。本研究旨在通过考虑透析和移植等因素，探讨CKD对儿童和青少年生长及青春期发育的影响。对52例年龄在0至18岁的儿科患者进行了一项横断面回顾性研究；这些患者被诊断为2至5期CKD，正在接受透析治疗或肾脏移植。还收集了人口统计学信息、临床特征、青春期发育情况及治疗方法。并分析了这些因素与青春期发育之间的关系。本研究显示，患有CKD的儿童和青少年在生长和青春期发育方面存在显著延迟。月经初潮的平均年龄为12.79岁，32.8%的患者有原发性闭经。接受透析和接受移植的患者表现出进一步的生长和青春期发育结果。CKD分期（r = 0.35；P = 0.02）和诊断时年龄（r = -0.28；P = 0.01）等因素显著影响CKD与青春期发育之间的关系。本研究结果与该人群青春期生长延迟有关。我们的研究结果强调了CKD对儿童和青少年生长及青春期发育的重大影响。对CKD及其并发症进行早期检测、干预和综合管理有助于改善这一脆弱人群的生长和青春期发育结果。
