纯母乳喂养与矫正年龄三岁时运动功能受损风险较低有关。
Exclusive human milk diet is associated with lower risk of motor function impairment at three years of corrected age.
作者信息
Chou Fu-Sheng, Zhang Jing, Villosis Maria Fe B, Lakshmanan Ashwini
机构信息
Southern California Permanente Medical Group, Pasadena, CA, USA.
Kaiser Permanente Southern California Department of Research and Evaluation, Pasadena, CA, USA.
出版信息
J Perinatol. 2025 Apr 21. doi: 10.1038/s41372-025-02296-z.
OBJECTIVES
To evaluate the association between an exclusive human milk diet (EHMD) and motor function impairment at three years of corrected age among infants born before 32 weeks of gestation.
METHODS
We conducted a retrospective study between 2018 and 2021. We assigned to the EHMD group infants who received an EHMD for ≥75% of the days between the first day of diet fortification and 33 6/7 weeks postmenstrual age. We used inverse propensity scores to balance potential confounders and developed a mixed-effects logistic regression model to assess the association.
RESULTS
After adjusting for demographics and morbidities, an EHMD was associated with a reduced risk of motor function impairment, with an odds ratio of 0.74 (95% CI: 0.56-0.98, p = 0.036).
CONCLUSIONS
An EHMD is associated with a decrease in the odds of early childhood motor function impairment among infants born before 32 weeks of gestation.
目的
评估纯母乳喂养（EHMD）与妊娠32周前出生的婴儿在矫正年龄三岁时运动功能障碍之间的关联。
方法
我们在2018年至2021年期间进行了一项回顾性研究。我们将在饮食强化第一天至月经后33又6/7周期间，接受纯母乳喂养≥75%天数的婴儿分配到纯母乳喂养组。我们使用逆倾向评分来平衡潜在的混杂因素，并建立了一个混合效应逻辑回归模型来评估这种关联。
结果
在调整了人口统计学和发病率因素后，纯母乳喂养与运动功能障碍风险降低相关，优势比为0.74（95%可信区间：0.56 - 0.98，p = 0.036）。
结论
纯母乳喂养与妊娠32周前出生的婴儿幼儿期运动功能障碍几率降低有关。
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