Hu Jie, Wang Long, Wu Jun-Cang
Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei), Hefei, Anhui, China.
Department of Neurology, The Fifth Clinical Medical College of Anhui Medical University, Hefei, Anhui, China.
Brain Behav. 2025 Apr;15(4):e70452. doi: 10.1002/brb3.70452.
To analysis the basic characteristics, comorbidities and prognosis of elderly patients with Late-Onset Epilepsy (LOE) in the Eastern Region of Hefei, Anhui.
This study finally selected 304 participants who were enrolled at the Second People's Hospital of Hefei between January 2018 and December 2023. The analysis included baseline characteristics, etiology, seizure types, findings from electroencephalography (EEG) and cranial magnetic resonance imaging, comorbidities, anti-seizure medication (ASM) regimens, and follow-up of seizure control outcomes within one year. Continuous variables were presented as mean ± standard deviation (SD) or median (IQR) based on normality. Categorical variables were compared using the chi-square test with Bonferroni correction for multiple comparisons.
According to our study, ischemic cerebral infarction (41.12%) was the main factor for LOE in elderly patients among structural factors. Focal seizure (92.76%) was the main seizure type. The most common comorbidity was ischemic cerebral infarction (88.16%), followed by cerebral hemorrhage (22.37%). During the one year follow-up, the overall effectiveness of seizure control was 73.03%, and 49.34% patients were seizure-free. The one-year treatment efficacy of patients with comorbid psychiatric disorders, cognitive impairment or dementia were significantly lower than that of patients without these comorbidities. In terms of medications, sodium valproate accounted for the most at 86.84%.
Structural factors are the main etiology for LOE in elderly patients, with ischemic cerebral infarction accounting for the highest proportion. Focal seizure was the main seizure type. Patients with comorbid psychiatric disorders, cognitive impairment or dementia may have poor one-year treatment efficacy.
分析安徽合肥东部地区老年迟发性癫痫（LOE）患者的基本特征、合并症及预后。
本研究最终选取了2018年1月至2023年12月期间在合肥市第二人民医院登记的304名参与者。分析内容包括基线特征、病因、发作类型、脑电图（EEG）和头颅磁共振成像结果、合并症、抗癫痫药物（ASM）治疗方案以及一年内癫痫控制结果的随访情况。连续变量根据正态性以均值±标准差（SD）或中位数（IQR）表示。分类变量采用卡方检验并进行Bonferroni校正以进行多重比较。
根据我们的研究，在结构性因素中，缺血性脑梗死（41.12%）是老年LOE患者的主要病因。局灶性发作（92.76%）是主要发作类型。最常见的合并症是缺血性脑梗死（88.16%），其次是脑出血（22.37%）。在一年的随访中，癫痫控制的总体有效率为73.03%，49.34%的患者无癫痫发作。合并精神障碍、认知障碍或痴呆的患者一年治疗疗效明显低于无这些合并症的患者。在药物方面，丙戊酸钠占比最高，为86.84%。
结构性因素是老年LOE患者的主要病因，其中缺血性脑梗死占比最高。局灶性发作是主要发作类型。合并精神障碍、认知障碍或痴呆的患者一年治疗疗效可能较差。
