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犬服用非班太尔相关的骨髓毒性：病例报告

Bone marrow toxicity associated with febantel administration in a dog: Case Report.

作者信息

Petronzio Abbey, Carabetta David, Koid Audrey

机构信息

MSPCA-Angell, Boston, MA, United States.

出版信息

Front Vet Sci. 2025 Apr 7;12:1557657. doi: 10.3389/fvets.2025.1557657. eCollection 2025.

DOI:10.3389/fvets.2025.1557657
PMID:40260210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12010925/
Abstract

INTRODUCTION

The objective of this case report is to describe a case of bone marrow suppression suspected to be secondary to febantel administration in a dog.

CASE SUMMARY

A 6-year-old neutered male Labrador Retriever was presented for lethargy and fever 15 days after receiving oral febantel. Pancytopenia was noted, and bone marrow sampling was consistent with hypoplasia suspected to be due to the febantel administration as no other toxic insults were identified. The dog made a full recovery in approximately 2 weeks after stopping the febantel.

DISCUSSION

This is the first report of suspected bone marrow toxicity secondary to febantel administration. Febantel is metabolized to fenbendazole, which has been documented as causing bone marrow toxicity in canines.

摘要

引言

本病例报告的目的是描述一例疑似因给犬使用非班太尔而导致骨髓抑制的病例。

病例摘要

一只6岁去势雄性拉布拉多猎犬在口服非班太尔15天后出现嗜睡和发热症状。发现全血细胞减少，骨髓采样结果与疑似因使用非班太尔导致的发育不全相符，因为未发现其他毒性损伤。该犬在停用非班太尔后约2周完全康复。

讨论

这是首例疑似因使用非班太尔导致骨髓毒性的报告。非班太尔代谢为芬苯达唑，芬苯达唑已被证明可导致犬类骨髓毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a30e/12010925/466b09e9f455/fvets-12-1557657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a30e/12010925/466b09e9f455/fvets-12-1557657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a30e/12010925/466b09e9f455/fvets-12-1557657-g001.jpg

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