Budsberg S C, Spurgeon T L, Liggitt H D
Am J Vet Res. 1985 Jul;46(7):1468-72.
Gross and microanatomic features which may predispose the German Shepherd Dog to perianal fistulae formation were studied in 2 groups of clinically healthy dogs: a predisposed group (German Shepherd Dogs) and a control group comprising breeds not ordinarily affected by perianal fistulae. The dimensions of the anal crypts (depth, base width, and length), measured and compared statistically between samples, identified no significant variation between groups (P greater than 0.05). Major tissue components of the anal canal were measured microscopically and were similarly evaluated: epithelial height in each zone, thickness of the lamina propria in each zone, thickness of the internal and external anal sphincter muscles, and density of the circumanal, sebaceous, and apocrine sweat glands. The only significant finding was an increase in density of apocrine sweat glands in the zona cutanea in the pre-disposed dog group. In a semiquantitative analysis of the inflammatory responses frequently seen in the anal glands, more mature fibroplasia was seen in the German Shepherd Dogs, indicating that inflammation was more longstanding in this group.
一组为易感组（德国牧羊犬），另一组为对照组，由通常不受肛周瘘影响的品种组成。对肛门隐窝的尺寸（深度、基部宽度和长度）进行测量并在样本间进行统计学比较，结果表明两组之间无显著差异（P大于0.05）。对肛管的主要组织成分进行显微镜测量并进行类似评估：每个区域的上皮高度、每个区域的固有层厚度、肛门内括约肌和外括约肌的厚度以及肛周、皮脂腺和顶泌汗腺的密度。唯一显著的发现是易感犬组皮肤区顶泌汗腺的密度增加。在对肛门腺中常见的炎症反应进行的半定量分析中，德国牧羊犬中可见更成熟的纤维组织增生，表明该组炎症持续时间更长。
