Zhong Xiaojuan, Fei Yujie, Zhao Haihui, Chen Jiao, Gao Mingyu, Huang Yi, Fei Wei
School of Medicine, University of Electronic Science and Technology, Chengdu, Sichuan, China.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Front Oncol. 2025 Apr 7;15:1529225. doi: 10.3389/fonc.2025.1529225. eCollection 2025.
Head and neck tumors represent a prevalent category of oral and maxillofacial malignancies, posing significant therapeutic and prognostic challenges due to their complex anatomical structure, tumor heterogeneity, and resistance to conventional therapies. Recent studies have highlighted the strong association between tumor progression and neoangiogenesis, with the angiopoietin (ANG) family playing a central role in this process. Comprising ANG1, ANG2, ANG3, and ANG4, these factors regulate multiple signaling pathways that promote cellular growth, differentiation, and proliferation, thereby driving angiogenesis and accelerating tumor growth and metastasis. Therefore, a comprehensive investigation of the ANG family's role in head and neck tumors may offer critical insights into tumorigenesis mechanisms and unveil novel therapeutic targets. Such research has the potential to improve treatment outcomes and enhance the quality of life for patients.
头颈部肿瘤是口腔颌面部恶性肿瘤的常见类型，由于其复杂的解剖结构、肿瘤异质性以及对传统疗法的耐药性，带来了重大的治疗和预后挑战。最近的研究强调了肿瘤进展与新生血管形成之间的紧密关联，血管生成素（ANG）家族在这一过程中起着核心作用。这些因子包括ANG1、ANG2、ANG3和ANG4，它们调节多种促进细胞生长、分化和增殖的信号通路，从而驱动血管生成并加速肿瘤生长和转移。因此，全面研究ANG家族在头颈部肿瘤中的作用，可能为肿瘤发生机制提供关键见解，并揭示新的治疗靶点。此类研究有潜力改善治疗效果并提高患者的生活质量。
