Qi Ping, Jiang Xiansen, Wang Xiaojuan, Sheng Liang, Liang Jiawen, Zhang Lei
The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, PR China.
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, PR China.
NPJ Biofilms Microbiomes. 2025 Apr 22;11(1):62. doi: 10.1038/s41522-025-00701-1.
High-altitude environments, characterized by hypobaric and hypoxic conditions, induce acute hypoxia, resulting in decreased blood oxygen saturation. This hypoxic stress perturbs gut microecological homeostasis, significantly contributing to the pathogenesis of acute mountain sickness. Consequently, elucidating the mechanisms by which high altitude affects gut homeostasis is crucial for developing effective interventions.
高海拔环境以低压和低氧为特征，会引发急性缺氧，导致血氧饱和度下降。这种缺氧应激会扰乱肠道微生态平衡，对急性高山病的发病机制有显著影响。因此，阐明高海拔影响肠道平衡的机制对于开发有效的干预措施至关重要。
