Cazzulani P, Panzarasa R, De Stefani C, Graziani G
Arch Int Pharmacodyn Ther. 1985 Apr;274(2):189-200.
In order to clarify the pharmacological activity of flavoxate, its effect on the tone and spontaneous activity of the guinea-pig isolated ureter and of the muscle strip from rat urinary bladder were studied. Flavoxate, as well as papaverine, reduced all three parameters considered on the guinea-pig isolated ureter, namely: peristaltic motility, endoluminal pressure and longitudinal muscle contractility. In the same test, verapamil (a calcium antagonist), emepronium and atropine (both anticholinergic drugs) were used for comparison. Using strips of rat urinary bladder depolarized by KCl, flavoxate, papaverine and verapamil displayed a relaxant activity, while anticholinergic compounds such as atropine, hyoscine and emepronium failed to relax this tissue. In another series of experiments the effects of flavoxate and anticholinergic drugs on the contraction elicited by vagal electrical stimulation of the guinea-pig isolated stomach in toto were assayed. The results obtained suggest that the action of flavoxate is due to direct smooth muscle relaxation and does not involve anticholinergic activity.
为阐明黄酮哌酯的药理活性，研究了其对豚鼠离体输尿管以及大鼠膀胱肌条的张力和自发活动的影响。黄酮哌酯与罂粟碱一样，降低了豚鼠离体输尿管所考察的三个参数，即：蠕动性、腔内压力和纵肌收缩性。在同一试验中，使用维拉帕米（一种钙拮抗剂）、依美溴铵和阿托品（两种抗胆碱能药物）作为对照。使用经氯化钾去极化的大鼠膀胱肌条，黄酮哌酯、罂粟碱和维拉帕米表现出舒张活性，而抗胆碱能化合物如阿托品、东莨菪碱和依美溴铵则不能使该组织舒张。在另一系列实验中，测定了黄酮哌酯和抗胆碱能药物对豚鼠离体全胃迷走神经电刺激所引起的收缩的影响。所得结果表明，黄酮哌酯的作用是由于直接使平滑肌舒张，而不涉及抗胆碱能活性。
