Vartanian A A, Kosorukov V S
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia, Moscow, 115478 Russian Federation.
Acta Naturae. 2025 Jan-Mar;17(1):4-10. doi: 10.32607/actanaturae.27547.
Ferroptosis, iron-dependent regulated cell death, is induced by the polyunsaturated fatty acid peroxidation of membrane phospholipids and is controlled by glutathione peroxidase 4. In recent years, convincing evidence has emerged, demonstrating a close relationship between chemo-, radio-, immuno-, and targeted therapy resistance and ferroptosis resistance. In this review, we discuss the basic principles of ferroptosis in cancer. Considerable attention is paid to the formation of an immunosuppressive tumor microenvironment. The main focus is centered on the involvement of the excessive, chronic production of pro-inflammatory cytokines in ferroptosis resistance development in tumors.
铁死亡是一种铁依赖性的程序性细胞死亡，由膜磷脂的多不饱和脂肪酸过氧化诱导，并受谷胱甘肽过氧化物酶4调控。近年来，越来越多的确凿证据表明，化疗、放疗、免疫治疗和靶向治疗耐药性与铁死亡抗性之间存在密切关系。在这篇综述中，我们讨论了癌症中铁死亡的基本原理。我们对免疫抑制性肿瘤微环境的形成给予了相当多的关注。主要关注点集中在促炎细胞因子的过度、慢性产生在肿瘤铁死亡抗性发展中的作用。
