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介入肿瘤学与免疫疗法:现状与未来展望

Interventional oncology and immunotherapy: current status and future perspectives.

作者信息

Ma Ji, Wei Zhigang, Ye Xin

机构信息

Department of Oncology, Lung Cancer Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.

Cheeloo College of Medicine, Shandong University, Jinan, China.

出版信息

Front Immunol. 2025 Apr 8;16:1541105. doi: 10.3389/fimmu.2025.1541105. eCollection 2025.

Abstract

Interventional oncology has become an important part of multidisciplinary cancer treatment following the development of interventional radiology. Tumors can release antigens, activate immunity, and cause an abscopal effect after interventional therapy. However, the activated immune response is limited and involves a complex process. New methods to solve the problems were developed following the advent of immunotherapy. The combination therapies enhanced the antitumor immune response and improved patient outcomes with good application prospects. In this review, we have summarized the interventional therapies used to improve immune efficacy and discussed the advancements in combining interventional therapy and immunotherapy.

摘要

随着介入放射学的发展,介入肿瘤学已成为多学科癌症治疗的重要组成部分。肿瘤在介入治疗后可释放抗原、激活免疫并产生远隔效应。然而,激活的免疫反应是有限的,且涉及一个复杂的过程。免疫疗法出现后,人们开发了新的方法来解决这些问题。联合疗法增强了抗肿瘤免疫反应,改善了患者预后,具有良好的应用前景。在这篇综述中,我们总结了用于提高免疫疗效的介入疗法,并讨论了介入疗法与免疫疗法联合应用的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c66d/12011731/e1d197452d2d/fimmu-16-1541105-g001.jpg

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