Xu Fengkuo, Wei Zhigang, Ye Xin
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute Jinan 250014, Shandong, China.
Cheeloo College of Medicine, Shandong University Jinan 250033, Shandong, China.
Am J Cancer Res. 2024 Jun 15;14(6):2714-2730. doi: 10.62347/QJID8425. eCollection 2024.
Image-guided thermal ablation (IGTA) is an important treatment modality for interventional oncology. It is widely used for the treatment of solid tumors, such as liver, lung, breast, kidney, and thyroid cancers. IGTA include radiofrequency ablation, microwave ablation (MWA), cryoablation, and laser ablation. Compared with other energy sources, MWA has the advantage of a large ablative volume, short ablative time, and a low heat sink effect. MWA can also induce antitumor immunity; however, only a minority of patients derive a clinical benefit from it. Based on these data, the combination of MWA and immunotherapy has emerged as a promising new direction for cancer treatment. This review article focuses on current research on the combination of MWA and immunotherapy. The status of immune activation and related studies involving MWA for the treatment of various malignant tumors are discussed.
图像引导热消融（IGTA）是介入肿瘤学的一种重要治疗方式。它广泛应用于实体瘤的治疗，如肝癌、肺癌、乳腺癌、肾癌和甲状腺癌。IGTA包括射频消融、微波消融（MWA）、冷冻消融和激光消融。与其他能量源相比，MWA具有消融体积大、消融时间短和热沉效应低的优点。MWA还可诱导抗肿瘤免疫；然而，只有少数患者从中获得临床益处。基于这些数据，MWA与免疫疗法的联合已成为癌症治疗的一个有前景的新方向。这篇综述文章聚焦于MWA与免疫疗法联合的当前研究。讨论了免疫激活的状态以及涉及MWA治疗各种恶性肿瘤的相关研究。
