Study of Expression of in Myeloid Leukaemia.

UNLABELLED

Myeloid leukaemia (ML) is a cancer that occurs by the accumulation of abnormally multiplied myeloid cells in bone marrow, peripheral blood, and other related tissue. is a gene of the GCK family that has a role in apoptosis, along with other cellular functions like cellular differentiation, cell cycle, metabolism, and others.

OBJECTIVES

The objectives of this study were to count RBCs and WBCs, study expression in ML and control samples, and perform an in silico correlation study on the and genes.

METHODS

The counting of RBCs and WBCs was carried out using a hemacytometer, the expression of was studied using RT-PCR, and a correlation study was carried out using GEPIA.

RESULTS

RBC and WBC levels in ML differed from the control levels, and the expression of was found to be upregulated in ML in comparison to controls, with a 2.90-8.65-fold change, with a significant -value > 0.05. A positive correlation in expression was also found between and and genes, with a significant r value correlation.

CONCLUSIONS

From this study, it could be deduced that might have a role in ML pathogenesis, but further research is needed to study its role in the progression of the disease.