Plants are exposed to a diverse range of biotic stressors, including fungi, bacteria, nematodes, insects and viruses. To combat these enemies, plants have developed an arsenal of defense mechanisms over time, among which secondary metabolites are the most effective. Moreover, to overcome the negative impact of chemical pesticides, the plant's secondary metabolites can be harnessed to develop novel disease management strategies. Alkaloids, flavonoids, terpenes and essential oils are major pathogen/pest-responsive secondary metabolite classes in plants. Among these, saponins have shown significant potential in suppressing a wide range of plant pathogens. However, they are yet to be explored thoroughly compared to other secondary metabolites in plant defense, and therefore, a low number of disease control agents exist in agri-markets based on saponins. Thus, this review aims to rectify this bias by identifying and acknowledging the significance of saponins as being on par with other classes of secondary metabolites in plant defense systems. It also provides the first holistic review on the role of saponins with known mechanisms against all of the major plant pathogens/pests. Furthermore, this review discusses the potential of saponin-rich crops in providing eco-friendly pest/pathogen management products for integrated pest management (IPM) and prospectives on the potential of saponin derivatives in developing novel biocides for sustainable agriculture.