Chen Li-Fen, Lin Ching-En, Chung Chi-Hsiang, Chung Yong-An, Park Sonya Youngju, Chang Wei-Chou, Chang Chuan-Chia, Chang Hsin-An
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan, Taiwan.
Eur Arch Psychiatry Clin Neurosci. 2025 Apr 23. doi: 10.1007/s00406-025-02010-2.
This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia.
本研究使用功能近红外光谱技术（fNIRS）对阿戈美拉汀治疗的伴有快感缺失的抑郁症患者的脑血流特征进行了调查。通过斯奈斯·汉密尔顿快感缺失量表（SHAPS）和蒙哥马利-Åsberg抑郁评定量表5项版（MADRS 5项）评分评估快感缺失水平。所有84例患者在研究开始当天进行评估，并在研究开始后的第1、4和8周进行随访。基于图论的网络分析显示，与基线相比，治疗1周后2-back任务调制的全局效率（调整后B = 0.055，95%置信区间 = 0.043 - 0.066）和局部效率（调整后B = 0.066，95%置信区间 = 0.050 - 0.081）显著增加。此外，从基线到治疗后1周氧合血红蛋白（oxy-Hb）值的增加与左半球眶额皮质MADRAS 5项总分的降低呈正相关（r = - 0.307，p = 0.005）。我们的研究结果表明，眶额皮质异常的功能连接可能反映快感缺失的病理生理特征，并可作为快感缺失的临床生物标志物。
