Suppr超能文献

土耳其某中心发生的大规模汞中毒病例评估:症状学、治疗方法及随访过程

Evaluation of mass mercury poisoning cases occurring in a center in Türkiye: symptomatology, treatment methods, and follow-up processes.

作者信息

Kurt Fatih, Akcil Abdullah, Cangur Sengul, Yıldız Mustafa

机构信息

Pediatrics Clinic, Duzce University, Duzce, Turkey.

Pediatrics Clinic, Sakarya University Training and Research Hospital, Adapazarı, Sakarya, Turkey.

出版信息

Eur J Pediatr. 2025 Apr 23;184(5):309. doi: 10.1007/s00431-025-06143-3.

Abstract

Mercury (Hg) is a toxic heavy metal with extensive applications. In children, mercury exposure often occurs inadvertently through laboratories, thermometers, or fluorescent lamps. Inhalation of elemental mercury can affect the central nervous system and urinary system. Early diagnosis and treatment are crucial to prevent severe complications. A retrospective evaluation was conducted on 82 pediatric cases of mercury poisoning who presented to Bingöl State Hospital on January 15, 2020. Blood and urine mercury levels were measured. Patients with mercury levels > 10 μg/L received intravenous treatment with 2,3-dimercaptopropane sulfonic acid (DMPS) for 5 days. Plasma and urine mercury levels were analyzed before and after treatment. Adverse effects of treatment and follow-up processes were also examined. Of the patients, 43.9% were female, and 56.1% were male, with a mean age of 9.4 ± 3.2 years. A total of 42.7% of cases were symptomatic, with headache being the most common symptom (26.8%). Significant reductions in blood and urine mercury levels were observed after treatment (p < 0.001). Adverse effects of the drug were reported in 43.9% of cases, with nausea (50%) and itching (25%) being the most frequent.Conclusion: Chelation therapy was effective in significantly reducing mercury levels in cases of mercury poisoning. Adverse effects must be carefully managed, and long-term follow-up is essential. This study provides significant contributions to the literature on mass mercury poisoning cases.

摘要

汞(Hg)是一种应用广泛的有毒重金属。在儿童中,汞暴露常通过实验室、温度计或荧光灯等途径意外发生。吸入元素汞会影响中枢神经系统和泌尿系统。早期诊断和治疗对于预防严重并发症至关重要。对2020年1月15日就诊于宾格尔州立医院的82例儿童汞中毒病例进行了回顾性评估。测量了血液和尿液中的汞含量。汞含量>10μg/L的患者接受2,3-二巯基丙磺酸钠(DMPS)静脉治疗5天。分析了治疗前后的血浆和尿液汞含量。还检查了治疗和随访过程中的不良反应。患者中,43.9%为女性,56.1%为男性,平均年龄为9.4±3.2岁。共有42.7%的病例出现症状,头痛是最常见的症状(26.8%)。治疗后血液和尿液中的汞含量显著降低(p<0.001)。43.9%的病例报告了药物的不良反应,其中恶心(50%)和瘙痒(25%)最为常见。结论:螯合疗法在显著降低汞中毒病例的汞含量方面是有效的。必须谨慎处理不良反应,长期随访至关重要。本研究为大量汞中毒病例的文献做出了重要贡献。

相似文献

2
Acute Mercury Poisoning in a Group of School Children.
Pediatr Emerg Care. 2019 Oct;35(10):696-699. doi: 10.1097/PEC.0000000000001011.
4
Mercury poisoning.
Curr Probl Pediatr. 2000 Mar;30(3):91-9. doi: 10.1067/mps.2000.104054.
8
Mercury toxicity and treatment: a review of the literature.
J Environ Public Health. 2012;2012:460508. doi: 10.1155/2012/460508. Epub 2011 Dec 22.
10
Inorganic mercury poisoning associated with skin-lightening cosmetic products.
Clin Toxicol (Phila). 2011 Dec;49(10):886-91. doi: 10.3109/15563650.2011.626425. Epub 2011 Nov 9.

本文引用的文献

1
Mercury Exposure and Health Effects: What Do We Really Know?
Int J Mol Sci. 2025 Mar 5;26(5):2326. doi: 10.3390/ijms26052326.
2
Mercury intoxication and ophthalmic involvement: An update review.
Front Toxicol. 2023 Mar 31;5:1148357. doi: 10.3389/ftox.2023.1148357. eCollection 2023.
3
Gut as the target tissue of mercury and the extraintestinal effects.
Toxicology. 2023 Jan 15;484:153396. doi: 10.1016/j.tox.2022.153396. Epub 2022 Dec 13.
4
Characteristics, Treatment, and Prognosis of Elemental Mercury Intoxication in Children: A Single-Center Retrospective Study.
Pediatr Emerg Care. 2022 Oct 1;38(10):481-488. doi: 10.1097/PEC.0000000000002834. Epub 2022 Sep 2.
5
Functional consequences of lead and mercury exposomes in the heart.
Mol Aspects Med. 2022 Oct;87:101048. doi: 10.1016/j.mam.2021.101048. Epub 2021 Nov 14.
6
Mercury and Movement Disorders: The Toxic Legacy Continues.
Can J Neurol Sci. 2022 Jul;49(4):493-501. doi: 10.1017/cjn.2021.146. Epub 2021 Jun 24.
7
Characteristics and treatment of elemental mercury intoxication: A case series.
Health Sci Rep. 2021 Jun 4;4(2):e293. doi: 10.1002/hsr2.293. eCollection 2021 Jun.
8
Association between mercury exposure and thyroid hormones levels: A meta-analysis.
Environ Res. 2021 May;196:110928. doi: 10.1016/j.envres.2021.110928. Epub 2021 Feb 26.
9
Association between acute severe mercury poisoning and multiple organ failure.
Am J Transl Res. 2020 Aug 15;12(8):4347-4353. eCollection 2020.
10
Mercury intoxication resembling pediatric rheumatic diseases: case series and literature review.
Rheumatol Int. 2020 Aug;40(8):1333-1342. doi: 10.1007/s00296-020-04589-2. Epub 2020 Apr 27.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验