Campbell J R, Clarkson T W, Omar M D
JAMA. 1986 Dec 12;256(22):3127-30.
Two patients had heavy metal intoxication resulting from industrial exposure to mercury vapors. One patient remained asymptomatic despite high urinary mercury levels. The second presented with a documented toxic reaction, including abnormal electromyograms and hematuria. Treatment was begun with 2,3-dimercaptopropane-1-sulfonate, and investigational drug used under Food and Drug Administration guidelines (IND 19,276). Use in both patients resulted in a dramatic change in excretion half-life of the mercury, from 33.1 days before treatment to 11.2 days during therapy. No significant toxic effects related to drug therapy were observed. Clearing of hematuria and reversal of electromyographic abnormalities were prompt in the symptomatic patient. Therapy with 2,3-dimercaptopropane-1-sulfonate was effective in these two patients.
两名患者因职业接触汞蒸气而发生重金属中毒。一名患者尽管尿汞水平很高，但仍无症状。第二名患者出现了有记录的毒性反应，包括异常肌电图和血尿。治疗从使用2,3-二巯基丙烷-1-磺酸盐开始，这是一种根据美国食品药品监督管理局指南使用的研究性药物（研究性新药申请编号19,276）。两名患者使用该药物后，汞的排泄半衰期发生了显著变化，从治疗前的33.1天降至治疗期间的11.2天。未观察到与药物治疗相关的明显毒性作用。有症状的患者血尿迅速消失，肌电图异常得到逆转。2,3-二巯基丙烷-1-磺酸盐治疗对这两名患者有效。
