Hu Xinru, Wang Junwen, Ye Yuyang, Chen Xuefeng, Abulikemu Simayi, Yu Jiang, Zhao Yifei, Hu Teng, Peng Yong
Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, 610041, China.
J Thromb Thrombolysis. 2025 Apr;58(4):514-525. doi: 10.1007/s11239-025-03087-1. Epub 2025 Apr 23.
Although prior research has investigated the link between fibrinogen and mortality risk, there is a notable lack of long-term cohort studies. This study seeks to examine the relationship between plasma fibrinogen levels and all-cause mortality. Fibrinogen levels were divided into low and high groups based on the median and further categorized into quartiles. Kaplan-Meier analysis was employed for survival analysis, and hazard ratios (HRs) were calculated using the Cox proportional hazards model. Our study included 5,690 participants, divided into a lower fibrinogen group (fibrinogen ≤ 370 mg/dL, N = 2,851) and a higher fibrinogen group (fibrinogen > 370 mg/dL, N = 2,839). The survival probability of the lower fibrinogen group was higher than that of the higher group (70.98% vs. 47.98%, P < 0.0001). All-cause mortality was higher in the higher fibrinogen group compared to the low fibrinogen group (HR 1.26, 95% CI 1.09-1.45, P = 0.002). Compared to Q1, mortality risk increased in Q2 (HR 1.26, 95% CI 1.00-1.59, P = 0.05), Q3 (HR 1.39, 95% CI 1.15-1.69, P < 0.001), and Q4 (HR 1.51, 95% CI 1.23-1.87, P < 0.001). Higher fibrinogen levels correlate with an elevated risk of all-cause mortality, suggesting fibrinogen is a potential biomarker for mortality risk.
尽管先前的研究已经调查了纤维蛋白原与死亡风险之间的联系，但长期队列研究明显不足。本研究旨在探讨血浆纤维蛋白原水平与全因死亡率之间的关系。根据中位数将纤维蛋白原水平分为低、高两组，并进一步分为四分位数。采用Kaplan-Meier分析进行生存分析，并使用Cox比例风险模型计算风险比（HRs）。我们的研究纳入了5690名参与者，分为较低纤维蛋白原组（纤维蛋白原≤370mg/dL，N = 2851）和较高纤维蛋白原组（纤维蛋白原>370mg/dL，N = 2839）。较低纤维蛋白原组的生存概率高于较高纤维蛋白原组（70.98%对47.98%，P<0.0001）。较高纤维蛋白原组的全因死亡率高于低纤维蛋白原组（HR 1.26，95%CI 1.09-1.45，P = 0.002）。与第一四分位数相比，第二四分位数（HR 1.26，95%CI 1.00-1.59，P = 0.05）、第三四分位数（HR 1.39，95%CI 1.15-1.69，P<0.001）和第四四分位数（HR 1.51，95%CI 1.23-1.87，P<0.001）的死亡风险增加。较高的纤维蛋白原水平与全因死亡率风险升高相关，表明纤维蛋白原是死亡风险的潜在生物标志物。
