Andonian Brian J, Hippensteel Joseph A, Abuabara Katrina, Boyle Eileen M, Colbert James F, Devinney Michael J, Faye Adam S, Kochar Bharati, Lee Jiha, Litke Rachel, Nair Devika, Sattui Sebastian E, Sheshadri Anoop, Sherman Andrea N, Singh Namrata, Zhang Yinan, LaHue Sara C
Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC, USA.
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Geroscience. 2025 Feb;47(1):515-542. doi: 10.1007/s11357-024-01364-0. Epub 2024 Oct 1.
Inflammaging, a state of chronic, progressive low-grade inflammation during aging, is associated with several adverse clinical outcomes, including frailty, disability, and death. Chronic inflammation is a hallmark of aging and is linked to the pathogenesis of many aging-related diseases. Anti-inflammatory therapies are also increasingly being studied as potential anti-aging treatments, and clinical trials have shown benefits in selected aging-related diseases. Despite promising advances, significant gaps remain in defining, measuring, treating, and integrating inflammaging into clinical geroscience research. The Clin-STAR Inflammation Research Interest Group was formed by a group of transdisciplinary clinician-scientists with the goal of advancing inflammaging-related clinical research and improving patient-centered care for older adults. Here, we integrate insights from nine medical subspecialties to illustrate the widespread impact of inflammaging on diseases linked to aging, highlighting the extensive opportunities for targeted interventions. We then propose a transdisciplinary approach to enhance understanding and treatment of inflammaging that aims to improve comprehensive care for our aging patients.
炎症衰老，即衰老过程中慢性、渐进性低度炎症的一种状态，与多种不良临床结局相关，包括衰弱、残疾和死亡。慢性炎症是衰老的一个标志，并且与许多衰老相关疾病的发病机制有关。抗炎疗法也越来越多地作为潜在的抗衰老治疗方法进行研究，临床试验已显示出在某些衰老相关疾病中的益处。尽管取得了令人鼓舞的进展，但在定义、测量、治疗炎症衰老以及将其纳入临床老年科学研究方面仍存在重大差距。临床衰老炎症研究兴趣小组由一群跨学科临床科学家组成，其目标是推进与炎症衰老相关的临床研究，并改善以患者为中心的老年人护理。在此，我们整合了九个医学亚专业的见解，以说明炎症衰老对与衰老相关疾病的广泛影响，突出了靶向干预的广泛机会。然后，我们提出一种跨学科方法来加强对炎症衰老的理解和治疗，旨在改善对老年患者的综合护理。
