Johnson J T, Myers E N, Bedetti C D, Barnes E L, Schramm V L, Thearle P B
Arch Otolaryngol. 1985 Aug;111(8):534-7. doi: 10.1001/archotol.1985.00800100082012.
The incidence and prognostic significance of extracapsular spread (ECS) of tumor in cervical lymphatics was investigated. The surgical specimens from 349 patients treated for squamous cell carcinoma by radical neck dissection between 1978 and 1982 have been examined retrospectively. Follow-up data were available relative to recurrence rate, site of recurrence, and disease-free intervals. Fifty-nine percent of the patients with N1 cervical metastases had ECS. Patients were classified according to the histopathologic findings in the radical neck dissection specimens. The three groups identified were patients with normal nodes, patients with no ECS, and patients with ECS. The histopathologic evidence of ECS was associated with a statistically significant reduction in survival when compared with patients without ECS. The disease-free interval between treatment and the development of recurrent disease was shorter for patients with ECS than for patients with no ECS.
对宫颈淋巴管肿瘤的包膜外扩散（ECS）的发生率及其预后意义进行了研究。回顾性检查了1978年至1982年间349例接受根治性颈清扫术治疗鳞状细胞癌患者的手术标本。获得了关于复发率、复发部位和无病间期的随访数据。59%的N1期宫颈转移患者存在ECS。根据根治性颈清扫术标本的组织病理学结果对患者进行分类。确定的三组患者分别为淋巴结正常的患者、无ECS的患者和有ECS的患者。与无ECS的患者相比，ECS的组织病理学证据与生存率的统计学显著降低相关。有ECS的患者治疗与复发性疾病发生之间的无病间期比无ECS的患者短。
