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患有压迫性和挫伤性椎间盘疾病的麻痹犬的临床表现、预后和结局的比较分析

A Comparative Analysis of Clinical Presentation, Prognosis and Outcomes in Paralytic Dogs with a Compressive and a Contusive Intervertebral Disc Disease.

作者信息

Kurtscheidt Anna, Rupp Stefan, Müller Ute, Forterre Franck

机构信息

Division of Small Animal Surgery, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.

Neurology Department, Tierärzte IVC Evidensia GmbH Tierklinik Hofheim, 65719 Hofheim am Taunus, Germany.

出版信息

Vet Sci. 2025 Mar 19;12(3):287. doi: 10.3390/vetsci12030287.

DOI:10.3390/vetsci12030287
PMID:40266989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11946308/
Abstract

This retrospective study aims to investigate whether dogs with a contusive and dogs with a compressive intervertebral disc disease share comparable outcomes and prognoses when presenting with the same neurological grade. A total of 50 dogs with IVDE (compression group) and 45 dogs with ANNPE (contusion group) were included in this study. The protocol involved a thorough review of the medical records and CT/MRI images of the included dogs. Data encompassing signalment, initial clinical signs, post-diagnosis treatment and short-term outcomes (less than 8 months) were collected from the patient records. Information on long-term outcomes (more than 8 months) was obtained through interviews with the owners. Dogs in the compression group displayed clinical signs at a statistically significant younger age and were more likely to experience deteriorating neurological deficits compared to the contusion group. Conversely, dogs with contusions had a significantly higher incidence of external trauma history and vocalization at the onset of clinical signs. In both groups, the most affected spinal cord segment was T3-L3. The overall recovery rate to regain independent ambulation was 71% in the contusion group vs. 80% in the compression group. While some of the examined parameters revealed differences, most did not significantly differ between the groups.

摘要

这项回顾性研究旨在调查患有压迫性和挫伤性椎间盘疾病的犬只在呈现相同神经学分级时是否具有相似的结果和预后。本研究共纳入了50只患有椎间盘突出症(压迫组)的犬只和45只患有急性非化脓性神经炎(挫伤组)的犬只。该方案包括对纳入犬只的病历和CT/MRI图像进行全面审查。从患者记录中收集了包括信号特征、初始临床症状、诊断后治疗和短期结果(少于8个月)的数据。通过与犬主访谈获得了长期结果(超过8个月)的信息相较挫伤组,压迫组的犬只在统计学上更年轻的时候就出现了临床症状,并且更有可能出现神经功能缺损恶化的情况。相反,患有挫伤的犬只在临床症状出现时,有外部创伤史和发声的发生率显著更高。在两组中,受影响最严重的脊髓节段均为T3-L3。挫伤组恢复独立行走的总体恢复率为71%,而压迫组为80%。虽然一些检查参数显示出差异,但大多数参数在两组之间并无显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/276382131b12/vetsci-12-00287-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/8a1ee8d42076/vetsci-12-00287-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/f0d70d183a1f/vetsci-12-00287-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/276382131b12/vetsci-12-00287-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/8a1ee8d42076/vetsci-12-00287-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/f0d70d183a1f/vetsci-12-00287-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11946308/276382131b12/vetsci-12-00287-g003.jpg

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本文引用的文献

1
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Vet Radiol Ultrasound. 2023 Mar;64(2):283-293. doi: 10.1111/vru.13178. Epub 2023 Jan 20.
2
Outcomes of dogs with progressive myelomalacia treated with hemilaminectomy or with extensive hemilaminectomy and durotomy.行半椎板切除术或广泛半椎板切除术和硬脊膜切开术治疗进行性脊髓软化症犬的结果。
Vet Surg. 2021 Jan;50(1):81-88. doi: 10.1111/vsu.13514. Epub 2020 Sep 29.
3
Diagnostic Imaging in Intervertebral Disc Disease.
椎间盘疾病的诊断性影像学
Front Vet Sci. 2020 Oct 22;7:588338. doi: 10.3389/fvets.2020.588338. eCollection 2020.
4
Classification of Intervertebral Disc Disease.椎间盘疾病的分类
Front Vet Sci. 2020 Oct 6;7:579025. doi: 10.3389/fvets.2020.579025. eCollection 2020.
5
Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs.犬急性胸腰椎间盘突出症的当前治疗方法
Front Vet Sci. 2020 Sep 3;7:610. doi: 10.3389/fvets.2020.00610. eCollection 2020.
6
Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study.与椎间盘突出后完全感觉运动丧失的犬进行性骨髓软化症相关的风险因素:回顾性病例对照研究。
BMC Vet Res. 2019 Dec 3;15(1):433. doi: 10.1186/s12917-019-2186-0.
7
Predictors of urinary or fecal incontinence in dogs with thoracolumbar acute non-compressive nucleus pulposus extrusion.胸腰椎急性非压迫性髓核脱出犬尿失禁或粪失禁的预测因子。
J Vet Intern Med. 2019 Nov;33(6):2693-2700. doi: 10.1111/jvim.15626. Epub 2019 Oct 31.
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Acute hydrated non-compressive nucleus pulposus extrusion: what do we know so far?急性水化性非压迫性髓核突出:我们目前了解多少?
Vet Rec. 2017 Dec;181(22):591-593. doi: 10.1136/vr.j5494.
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retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.CFA12 上的返祖基因导致犬的软骨发育不良和椎间盘疾病。
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Vet Clin North Am Small Anim Pract. 2018 Jan;48(1):95-109. doi: 10.1016/j.cvsm.2017.08.004. Epub 2017 Sep 28.