Cortés-Torres Edgar Joaquín, Flores-Betancourt María Del Refugio, González-Ojeda Alejandro, Fuentes-Orozco Clotilde, Cervantes-Guevara Gabino, Cervantes-Pérez Enrique, Ramírez-Velázquez Alejandro, Hernández-Guzmán Ana Karen
Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Hospital de Especialidades "Lic. Ignacio García Téllez", Servicio de Cirugía Oncológica. Guadalajara, Jalisco, México.
Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Hospital de Especialidades "Lic. Ignacio García Téllez", Unidad de Investigación Biomédica 02. Guadalajara, Jalisco, México.
Rev Med Inst Mex Seguro Soc. 2025 Jan 3;63(1):e6321. doi: 10.5281/zenodo.14200044.
Colorectal cancer (CRC) is one of the most common and lethal neoplasia in the world. Key prognostic factors include lymphovascular and perineural infiltration, which negatively affect the disease by increasing the risk of metastasis. Studies indicate that low levels of CD8+ and CD3+ T cells may be associated with early metastasis.
To evaluate the sensitivity and specificity of preoperative serum cytotoxic T lymphocytes (CD8+ and CD3+) with lymphatic and perineural infiltration in colorectal cancer.
Prospective, cross-sectional, analytical study on cytotoxic T lymphocytes (CD8+ and CD3+). Descriptive statistics, measures of central tendency and dispersion for quantitative variables, frequency and percentage for qualitative variables were used. The samples obtained were associated with the presence of lymphovascular or perineural infiltration.
37 patients were included, with a mean age of 58 ± 10.9 years; 24 (64.8%) were female. 16 (43.2%) were diagnosed with malignant colon neoplasms, and 21 (56.7%) with malignant rectal tumors. Lymphovascular infiltration was found in 13 (35.1%) and 18 (48.6%) perineural infiltrates. CD8+ T lymphocyte levels were 219 cells/AL ± 140.5 cells/AL, and 16 (43.2%) had low levels. CD3+ T lymphocytes averaged with 943 cells/uL ± 640.4 cells/AL, and 16 (43.2%) had low levels.
Histopathologically we found an association between the serum level of CD3+ and CD8+ T cells and lymphovascular and perineural infiltration. Additional research has to be done to strengthen the results obtained.
结直肠癌（CRC）是世界上最常见且致命的肿瘤之一。关键预后因素包括淋巴管和神经周围浸润，其通过增加转移风险对疾病产生负面影响。研究表明，低水平的CD8 +和CD3 + T细胞可能与早期转移有关。
评估术前血清细胞毒性T淋巴细胞（CD8 +和CD3 +）对结直肠癌淋巴管和神经周围浸润的敏感性和特异性。
对细胞毒性T淋巴细胞（CD8 +和CD3 +）进行前瞻性、横断面分析研究。使用描述性统计、定量变量的集中趋势和离散度测量、定性变量的频率和百分比。所获得的样本与淋巴管或神经周围浸润的存在相关。
纳入37例患者，平均年龄58±10.9岁；24例（64.8%）为女性。16例（43.2%）被诊断为结肠恶性肿瘤，21例（56.7%）为直肠恶性肿瘤。发现13例（35.1%）有淋巴管浸润，18例（48.6%）有神经周围浸润。CD8 + T淋巴细胞水平为219个细胞/μL±140.5个细胞/μL，16例（43.2%）水平较低。CD3 + T淋巴细胞平均为943个细胞/μL±640.4个细胞/μL，16例（43.2%）水平较低。
组织病理学上，我们发现CD3 +和CD8 + T细胞的血清水平与淋巴管和神经周围浸润之间存在关联。必须进行更多研究以加强所得结果。
