Kierkels Roel G J, Hilgers Guido C, Angerud Agnes, Fälth Claes, Minken André
Radiotherapiegroep, Arnhem/Deventer, The Netherlands.
RaySearch Laboratories AB, Stockholm, Sweden.
Phys Med Biol. 2025 May 2;70(9). doi: 10.1088/1361-6560/adcfed.
MR-guided adaptive radiotherapy (MRgART) is ideally suited to adjust the treatment plan for anatomical changes. The online nature of MRgART involves multiple process steps during each treatment fraction, which may greatly benefit from automation. TheRayStationtreatment planning system incorporates automation features by design, but requires dose calculations in the presence of an external magnetic field and the modeling of the MRgART system. This study developed and commissioned a comprehensive model for the 1.5 T MR-guided linear accelerators (MR-linacs) inRayStation.MR-linac dose profiles and output factors were used to model the Unity MR-linac inRayStation. The MR cryostat was implemented in the Monte Carlo simulation as a multi-layer barrel, adjusted using simulations and in-air output measurements. The cryostat transmission variation with gantry angle was added as a fluence correction. Dose distributions of on-axis square, off-axis square, and 90 IMRT fields of ten prostate MR-linac treatment plans were evaluated with the PTW Octavius 1500MR detector array. The radiofrequency coils and couch were characterized with megavoltage imager transmission measurements. CT scans of the coils were used to model its geometry inRayStationand mass densities were assigned to match the measured attenuation.Differences between measured and calculated depth dose showed a< 0.5 beyond. For both the inline and crossline profiles, theevaluation exhibited a< 1.0 for nearly all evaluated points. The maximum difference between the measured and calculated cryostat scatter was 0.6%. The averagepass rate for the on-axis, off-axis, and IMRT fields was >98.3% (range: 91.2%-100%). The average coil transmissions were 0.6 (anterior) and 2.2% (posterior).We successfully modeled and commissioned the 1.5 T MR-linac inRayStationwell within tolerance limits as specified by the American Association of Physicists in Medicine TG-157 report.
磁共振引导自适应放疗(MRgART)非常适合针对解剖结构变化调整治疗计划。MRgART的在线特性意味着在每个治疗分次期间都涉及多个处理步骤,自动化可使其受益匪浅。RayStation治疗计划系统在设计时就融入了自动化功能,但需要在存在外部磁场的情况下进行剂量计算以及对MRgART系统进行建模。本研究针对RayStation中的1.5T磁共振引导直线加速器(MR直线加速器)开发并启用了一个综合模型。利用MR直线加速器的剂量分布曲线和输出因子在RayStation中对Unity MR直线加速器进行建模。在蒙特卡罗模拟中,将MR低温恒温器实现为一个多层桶状结构,并通过模拟和空气中输出测量进行调整。低温恒温器传输随机架角度的变化作为注量校正添加进去。使用PTW Octavius 1500MR探测器阵列评估了十个前列腺MR直线加速器治疗计划的轴上方形野、离轴方形野和90野调强放疗野的剂量分布。通过兆伏级成像器传输测量对射频线圈和治疗床进行了特性描述。利用线圈的CT扫描在RayStation中对其几何结构进行建模,并指定质量密度以匹配测量的衰减。测量深度剂量与计算深度剂量之间的差异在超过某一值后小于0.5%。对于行内和行外轮廓,几乎所有评估点的评估结果均显示差异小于1.0%。测量的和计算的低温恒温器散射之间的最大差异为0.6%。轴上野、离轴野和调强放疗野的平均通过率>98.3%(范围:91.2% - 100%)。线圈的平均传输率分别为0.6%(前部)和2.2%(后部)。我们成功地在RayStation中对1.5T MR直线加速器进行了建模和启用,且完全在医学物理师协会TG - 157报告规定的公差范围内。