雄性大鼠中肾毒性碳氢化合物2,2,4-三甲基戊烷的尿液代谢物鉴定

Identification of urinary metabolites of the nephrotoxic hydrocarbon 2,2,4-trimethylpentane in male rats.

作者信息

Olson C T, Yu K O, Hobson D W, Serve M P

出版信息

Biochem Biophys Res Commun. 1985 Jul 16;130(1):313-6. doi: 10.1016/0006-291x(85)90419-x.

Abstract

The compound 2,2,4-trimethylpentane (2,2,4 TMP) is reported to be especially potent in inducing kidney lesions in male rats (1,2). Although the pathology produced by 2,2,4 TMP has been examined (1), there are no reports concerning the metabolism of 2,2,4 TMP by the male rat. The eight principal urinary metabolites of 2,2,4 TMP found in the urine of Fischer 344 male rats are: 2,2,4-trimethyl-1-pentanol, 2,4,4-trimethyl-1-pentanol, 2,4,4-trimethyl-2-pentanol, 2,2,4-trimethyl-1-pentanoic acid, 2,4,4-trimethyl-1-pentanoic acid, 2,4,4-trimethyl-2-hydroxy-1-pentanoic acid, 2,2,4-trimethyl-5-hydroxy-1-pentanoic acid and 2,4,4-trimethyl-5-hydroxy-1-pentanoic acid.

摘要

据报道，化合物2,2,4-三甲基戊烷（2,2,4 TMP）在诱导雄性大鼠肾脏损伤方面具有特别强的作用（1,2）。尽管已经对2,2,4 TMP产生的病理学进行了研究（1），但尚无关于雄性大鼠对2,2,4 TMP代谢的报道。在Fischer 344雄性大鼠尿液中发现的2,2,4 TMP的八种主要尿代谢物为：2,2,4-三甲基-1-戊醇、2,4,4-三甲基-1-戊醇、2,4,4-三甲基-2-戊醇、2,2,4-三甲基-1-戊酸、2,4,4-三甲基-1-戊酸、2,4,4-三甲基-2-羟基-1-戊酸、2,2,4-三甲基-5-羟基-1-戊酸和2,4,4-三甲基-5-羟基-1-戊酸。