雄性费希尔344大鼠体内2,3,4-三甲基戊烷的代谢

The metabolism of 2,3,4-trimethylpentane in male Fischer-344 rats.

作者信息

Olson C T, Hobson D W, YU K O, Serve M P

出版信息

Toxicol Lett. 1987 Aug;37(3):199-202. doi: 10.1016/0378-4274(87)90132-9.

Abstract

The urinary metabolites of the potent nephrotoxic hydrocarbon 2,3,4-trimethylpentane (2,3,4-TMP) given Fischer-344 male rats by gavage included 1-hydroxy-2,3,4-trimethylpentane, 2,3,4-trimethyl-1-pentanoic acid and 2,3,4-trimethyl-5-hydroxy-1-pentanoic acid. Analyses were performed by gas-liquid chromatography (GC) and gas-liquid chromatography/mass spectrometry (GC/MS). A comparison of the urinary metabolites of 2,3,4-TMP with those of 2,2,4-trimethylpentane (2,2,4-TMP) showed that more monocarboxylic acid was produced with 2,3,4-TMP.

摘要

通过灌胃给予雄性Fischer - 344大鼠强效肾毒性烃类2,3,4 - 三甲基戊烷（2,3,4 - TMP）后，其尿液代谢产物包括1 - 羟基 - 2,3,4 - 三甲基戊烷、2,3,4 - 三甲基 - 1 - 戊酸和2,3,4 - 三甲基 - 5 - 羟基 - 1 - 戊酸。分析采用气液色谱法（GC）和气液色谱/质谱联用法（GC/MS）。2,3,4 - TMP与2,2,4 - 三甲基戊烷（2,2,4 - TMP）尿液代谢产物的比较表明，2,3,4 - TMP产生的一元羧酸更多。