Buchta R, Fridkin M
Biochem Biophys Res Commun. 1985 Jul 16;130(1):350-7. doi: 10.1016/0006-291x(85)90424-3.
Two dansyl derivatives: 1-(5-dimethylaminonaphthalene) sulfonyl (4-amino)-benzyl amine and 1-(5-dimethylaminonaphthalene) sulfonyl beta(4-aminophenyl) ethylamine, have been recently synthesized. Reaction of these compounds with nitrous acid lead to the corresponding dansyl-bearing diazonium salts. The latter derivatives can couple, under mild basic conditions, to the imidazole moiety of histidine, the phenolic ring of tyrosine and to the epsilon-amino function of lysine. The applicability of the two reagents was tested in the modification of several peptides, including [D-Phe6]LHRH, [D-Gln6]LHRH, Leu-enkephalin and Tyr-tuftsin, and proteins such as calmodulin, bovine serum albumin and nerve growth factor.
1-(5-二甲基氨基萘)磺酰基(4-氨基)-苄胺和1-(5-二甲基氨基萘)磺酰基β(4-氨基苯基)乙胺。这些化合物与亚硝酸反应生成相应的含丹磺酰基的重氮盐。后一种衍生物在温和的碱性条件下可与组氨酸的咪唑部分、酪氨酸的酚环以及赖氨酸的ε-氨基官能团偶联。在几种肽（包括[D-苯丙氨酸6]促黄体生成素释放激素、[D-谷氨酰胺6]促黄体生成素释放激素、亮氨酸脑啡肽和酪氨酰-吞噬细胞调理素）以及蛋白质（如钙调蛋白、牛血清白蛋白和神经生长因子）的修饰中测试了这两种试剂的适用性。
