在一例伴有预先存在抗SOX1抗体的广泛期小细胞肺癌患者中，免疫检查点抑制剂相关副肿瘤性小脑变性。
Immune checkpoint inhibitor-associated paraneoplastic cerebellar degeneration in a case of extensive-stage small-cell lung cancer with pre-existing anti-SOX1 antibody.
作者信息
Nii Kaori, Ogino Hirokazu, Bando Hiroki, Yamamoto Yuki, Fujita Koji, Yoneda Hiroto, Naito Nobuhito, Mitsuhashi Atsushi, Morita Yutaka, Tsukazaki Yuki, Yabuki Yohei, Ozaki Ryohiko, Sato Seidai, Hanibuchi Masaki, Izumi Yuishin, Nishioka Yasuhiko
机构信息
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Department of Neurology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
出版信息
J Med Invest. 2025;72(1.2):172-176. doi: 10.2152/jmi.72.172.
Neurological immune-related adverse events can manifest as paraneoplastic neurological syndrome (PNS), especially in patients with small-cell lung cancer (SCLC). We herein report a 73-year-old man with SCLC treated with an immune checkpoint inhibitor (ICI) combined with chemotherapy. Although the chemo-immunotherapy induced a favorable response to SCLC, he later developed acute cerebellar ataxia. He was diagnosed with paraneoplastic cerebellar degeneration associated with anti-Sry-like high mobility group box 1 (SOX1) autoantibody. The antibody was also identified in serum collected at the diagnosis of SCLC and before ICI administration, which retrospectively suggested that the patient was at risk of ICI-induced PNS. J. Med. Invest. 72 : 172-176, February, 2025.
神经免疫相关不良事件可表现为副肿瘤性神经综合征（PNS），尤其是在小细胞肺癌（SCLC）患者中。我们在此报告一名73岁的SCLC男性患者，接受了免疫检查点抑制剂（ICI）联合化疗。尽管化学免疫疗法对SCLC产生了良好反应，但他后来出现了急性小脑共济失调。他被诊断为与抗Sry样高迁移率族蛋白盒1（SOX1）自身抗体相关的副肿瘤性小脑变性。在SCLC诊断时及ICI给药前采集的血清中也发现了该抗体，这一回顾性结果提示该患者有发生ICI诱导的PNS的风险。《医学调查杂志》72: 172 - 176，2025年2月。
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