The characterization of [3H]sulpiride binding sites in pig striatal membranes.
作者信息
Holden-Dye L, Poat J A, Senior K, Woodruff G N
出版信息
Biochem Pharmacol. 1985 Aug 15;34(16):2905-9. doi: 10.1016/0006-2952(85)90014-0.
PMID:4026877
Abstract
Pig striatal membranes have [3H]sulpiride-binding sites similar to those identified in rat striatal membranes. The pharmacological profile indicates that this binding is to dopamine receptors. Agonist displacement of [3H]sulpiride binding in pig striatal membranes is subject to guanine nucleotide regulation. This effect is mimicked by heat treatment. N-ethyl maleamide (20 microM) and dithioerythritol (3 mM) decrease agonist affinity for the [3H]sulpiride-binding site in pig striatal membranes without significantly affecting maximal displacement.
摘要
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