Xiong Xiuqin, Huang Li, Carvalho Natalie, Dalziel Kim, Devlin Nancy
Melbourne Health Economics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Pharmacoeconomics. 2025 Apr 23. doi: 10.1007/s40273-025-01494-z.
This study aims to test whether preferences for children's health states differ (a) when considering those aged 2-4 years compared with older children and (b) by parental status; we also aim to provide a value set that can be used for 2-4 years old.
Health states were described using the Child Health Utility 9D (CHU9D). A discrete choice experiment (DCE) survey was administered between September 2023 and March 2024 to a representative sample of the Australian general adult population which included a 20% quota of parents of 0-18-year-old children. Participants were randomly allocated to two study arms considering the health of a 2-4-year-old or a 10-year-old child. A conditional logit model was used to obtain the latent values from the choice responses. The differences in latent values between the two ages and between parental status were analyzed using relative attribute importance (RAI), poolability test, and pooled model with interaction terms. Visual Analogue Scale (VAS) responses were used to anchor the latent values onto a 0-1 utility scale.
In all, 3112 participants were included. Results suggested that the preferences between the two age perspectives were similar, with only 1 out of 36 interaction terms being significant. Preferences of parents of children aged 0-18 years differed from those who were not, as indicated by three significant interaction terms and failure in poolability testing, having smaller disutility for severe health states in the Pain, Tired, and Joining in Activities dimensions.
In the valuation of CHU9D health states, asking respondents to consider a 2-4-year-old compared with a 10-year-old did not influence adults' preferences; however, the preferences of respondents who were parents of 0-18-year-olds at that time differed from those who were not. Two CHU9D value sets are reported for children 2 years and older, one derived from the general adult population and the other from parents.
本研究旨在测试(a)在考虑2至4岁儿童与大龄儿童时,对儿童健康状态的偏好是否存在差异;以及(b)偏好是否因父母身份而不同;我们还旨在提供一个可用于2至4岁儿童的价值集。
使用儿童健康效用9维度量表(CHU9D)描述健康状态。在2023年9月至2024年3月期间,对澳大利亚普通成年人口的代表性样本进行了离散选择实验(DCE)调查,其中包括20%的0至18岁儿童家长配额。参与者被随机分配到两个研究组,分别考虑2至4岁儿童或10岁儿童的健康状况。使用条件logit模型从选择反应中获取潜在值。使用相对属性重要性(RAI)、可合并性检验以及带有交互项的合并模型分析两个年龄组之间以及父母身份之间潜在值的差异。使用视觉模拟量表(VAS)反应将潜在值锚定在0至1的效用量表上。
总共纳入了3112名参与者。结果表明,两种年龄视角下的偏好相似,36个交互项中只有1个显著。0至18岁儿童家长的偏好与非家长的偏好不同,这由三个显著的交互项以及可合并性检验未通过表明,在疼痛、疲劳和参与活动维度中,家长对严重健康状态的负效用较小。
在CHU9D健康状态的估值中,要求受访者考虑2至4岁儿童与10岁儿童相比,并未影响成年人的偏好;然而,当时是0至18岁儿童家长的受访者的偏好与非家长的受访者不同。报告了两个适用于2岁及以上儿童的CHU9D价值集,一个来自普通成年人群体,另一个来自家长群体。