Jirimali Harishchandra, Santre Saiprasad, Deonikar Shubhangi, More Bhausaheb
Regional Forensic Science Laboratory, Nanded, MS, India, 431601.
Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, MS, India, 431602.
Forensic Sci Med Pathol. 2025 Jun;21(2):971-978. doi: 10.1007/s12024-025-00991-z. Epub 2025 Apr 23.
This aims to study poisoning cases involving bromadiolone, its detection from biological samples, and treatment for the survival of the victim.
A literature survey on bromadiolone poisoning using Scopus, PubMed, and World Wide Web using relevant keywords, e.g. Bromadiolone poisoning, bromadiolone toxicology, poisoning treatment, bromadiolone detection, detection methods. The analytical methods like thin layer chromatography, high performance liquid chromatography, gas chromatography, CT scans (computed tomography scan) Magnetic Resonance Imaging (MRI) and combined mass spectroscopic methods were used for the detection of bromadiolone.
Bromadiolone poisoning in different organisms like cats, rats, birds, foxes, and human beings was studied. On the basis of the concentration of bromadiolone and its half-life period, symptoms like internal hemorrhage were observed; in some cases, lesions on the brain were seen. Vitamin K (Vit. K), is the effective treatment for the curing of bromadiolone, was identified.
This review suggests that in the case of bromadiolone poisoning, it is very important to find out the poisoned compound and not to rely only on symptomatic treatment. It is found that Vit. K is the major curative treatment for the survival of bromadiolone poisoning victims.
本研究旨在探讨涉及溴敌隆的中毒病例、从生物样本中检测溴敌隆以及为中毒者的存活进行治疗。
使用Scopus、PubMed以及互联网，通过相关关键词（如溴敌隆中毒、溴敌隆毒理学、中毒治疗、溴敌隆检测、检测方法）对溴敌隆中毒进行文献调研。采用薄层色谱法、高效液相色谱法、气相色谱法、CT扫描（计算机断层扫描）、磁共振成像（MRI）以及联用质谱法等分析方法检测溴敌隆。
研究了溴敌隆在猫、大鼠、鸟类、狐狸和人类等不同生物体中的中毒情况。根据溴敌隆的浓度及其半衰期，观察到内出血等症状；在某些情况下，还发现脑部有病变。已确定维生素K是治疗溴敌隆中毒的有效药物。
本综述表明，在溴敌隆中毒的情况下，找出中毒化合物非常重要，不能仅依赖对症治疗。研究发现，维生素K是溴敌隆中毒受害者存活的主要治疗药物。
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