Cameron B D, Johnston A M, Speirs G, Ludwig G
Arzneimittelforschung. 1985;35(6):953-7.
The investigations were designed to evaluate the systemic absorption of two steroids from suppositories. The suppositories containing either 3H-hydrocortisone (1 mg) or 3H-prednisolone-21-hexanoate (1 mg) were administered to a group of 4 baboons restrained in chairs. The levels of radio-activity in the plasma and urine were measured up to 120 h following rectal administration, and these levels were compared with those of a subsequent intravenous administration (1 mg each). The results show that both hydrocortisone (H) and prednisolone-21-hexanoate (P) are rapidly (tmax = 2-3 h) and significantly (H: 60-78%, P: 47-58%) absorbed from suppositories and thus can also cause systemic effects.
这些研究旨在评估两种类固醇从栓剂中的全身吸收情况。将含有3H-氢化可的松（1毫克）或3H-泼尼松龙-21-己酸酯（1毫克）的栓剂给予一组4只被束缚在椅子上的狒狒。在直肠给药后长达120小时测量血浆和尿液中的放射性水平，并将这些水平与随后静脉给药（各1毫克）的水平进行比较。结果表明，氢化可的松（H）和泼尼松龙-21-己酸酯（P）均从栓剂中迅速（达峰时间=2 - 3小时）且显著（H：60 - 78%，P：47 - 58%）吸收，因此也可产生全身效应。
