Yao Hang, Chen Jiahao, Wang Yu, Li Yuxin, Tang Peiyu, Liang Mingpeng, Jiang Qingling
School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, China.
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
BMC Pregnancy Childbirth. 2025 Apr 23;25(1):479. doi: 10.1186/s12884-025-07608-x.
Pre-eclampsia (PE) and pregnancy hypertension (PH) are common and serious complications during pregnancy, which can lead to maternal and fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE and PH is of great significance for developing new treatment strategies.
This study used the summary data-based Mendelian randomization (SMR) method to analyze expression quantitative trait loci (eQTL) data from blood, aorta, and uterus with Genome-wide association studies (GWAS) data on PE and PH, exploring potential genetic loci involved in PE and PH. Since proteinuria is a clinical manifestation of PE, we also analyzed genes related to the kidney and PE. The HEIDI test was used for heterogeneity testing, and results were adjusted using FDR. The cis-eQTL data were obtained from the blood summary-level data of the eQTLGen Consortium and the aorta and uterus data from the V8 release of the GTEx eQTL summary data. The GWAS data for PE and PH were obtained from the FinnGen Documentation of R10 release. This study utilized the STROBE-MR checklist for reporting Mendelian Randomization (MR) studies.
This study identified several potential therapeutic targets by integrating eQTL data from blood, uterus, and aorta with GWAS data for PE and PH, as well as kidney eQTL data with GWAS data for PE. Additionally, the study discovered some genes with common roles in PE and PH, offering new insights into the shared pathological mechanisms of these two conditions. These findings not only provide new clues to the pathogenesis of PE and PH but also offer crucial foundational data for the development of future therapeutic strategies.
This study revealed multiple potential therapeutic targets for PE and PH, providing new insights for basic experimental research and clinical treatment to mitigate the severe consequences of PE and PH.
Not applicable.
子痫前期（PE）和妊娠高血压（PH）是妊娠期常见且严重的并发症，严重时可导致母婴死亡。因此，进一步研究PE和PH的潜在治疗靶点对于开发新的治疗策略具有重要意义。
本研究采用基于汇总数据的孟德尔随机化（SMR）方法，将血液、主动脉和子宫的表达定量性状位点（eQTL）数据与PE和PH的全基因组关联研究（GWAS）数据进行分析，探索参与PE和PH的潜在基因位点。由于蛋白尿是PE的一种临床表现，我们还分析了与肾脏和PE相关的基因。采用HEIDI检验进行异质性检验，并使用FDR对结果进行校正。顺式eQTL数据来自eQTLGen联盟的血液汇总水平数据以及GTEx eQTL汇总数据V8版本的主动脉和子宫数据。PE和PH的GWAS数据来自FinnGen R10版本的文档。本研究使用STROBE-MR清单报告孟德尔随机化（MR）研究。
本研究通过将血液、子宫和主动脉的eQTL数据与PE和PH的GWAS数据以及肾脏eQTL数据与PE的GWAS数据相结合，确定了几个潜在的治疗靶点。此外，该研究还发现了一些在PE和PH中具有共同作用的基因，为这两种疾病的共同病理机制提供了新的见解。这些发现不仅为PE和PH的发病机制提供了新线索，也为未来治疗策略的开发提供了关键的基础数据。
本研究揭示了PE和PH的多个潜在治疗靶点，为基础实验研究和临床治疗提供了新的见解，以减轻PE和PH的严重后果。
不适用。
