Rockwood G A, Riley E P
Alcohol. 1985 Jul-Aug;2(4):575-9. doi: 10.1016/0741-8329(85)90083-7.
The behavioral effects of the anticholinergic scopolamine were examined in rats exposed to alcohol prenatally. Pregnant Long-Evans rats received isocaloric liquid diets containing either 35% or 0% ethanol-derived calories on Days 6-20 of gestation. A pair-feeding procedure was used, and a lab chow control group was also included. In Experiment 1, adult offspring were tested on a spontaneous alternation task following 1 mg/kg scopolamine or saline. Independent of prenatal treatment, scopolamine caused an increase in the number of trials to alternate. In Experiment 2, offspring were tested on a two-way shuttle avoidance learning task following a 1 mg/kg injection of scopolamine or methylscopolamine. Alcohol-exposed animals injected with methylscopolamine made fewer avoidances than controls on the second day of testing while treatment with scopolamine enhanced avoidance performance to control levels. These data suggest that prenatal exposure to alcohol does not interfere with scopolamine-induced changes in the behavior of adult rats.
研究了抗胆碱能药物东莨菪碱对产前暴露于酒精的大鼠行为的影响。怀孕的Long-Evans大鼠在妊娠第6至20天接受含有35%或0%乙醇热量的等热量液体饮食。采用配对喂养程序，还设立了实验室普通饲料对照组。在实验1中，成年后代在接受1mg/kg东莨菪碱或生理盐水后，进行自发交替任务测试。与产前处理无关，东莨菪碱导致交替试验次数增加。在实验2中，后代在注射1mg/kg东莨菪碱或甲基东莨菪碱后，进行双向穿梭回避学习任务测试。注射甲基东莨菪碱的酒精暴露动物在测试的第二天比对照组做出的回避反应更少，而用东莨菪碱治疗可将回避表现提高到对照组水平。这些数据表明，产前暴露于酒精不会干扰东莨菪碱诱导的成年大鼠行为变化。
