Lattanzio Katie, Alkhatib Khalid, Guzzo Tom, Lee Daniel J, Pierorazio Phil, Bivalacqua Trinity, Schurhamer Ben
Division of Urology, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Urol Case Rep. 2025 Mar 25;60:103023. doi: 10.1016/j.eucr.2025.103023. eCollection 2025 May.
Pulsed Electric Field (PEF) ablation is an emerging non-thermal ablation device with previous uses in lung, liver and sarcoma cancers. We present a case of prostate cancer recurrence post-radiation managed with PEF ablation. Under transperineal guidance, targeted PEF was delivered to the area of concern on previous biopsies and PSMA. In follow up the patient had a marked decline in PSA levels and resolution on follow-up PSMA. The patient experienced no significant side effects, preserving urinary continence and sexual function. These outcomes underscore PEF ablation's potential as a safe and effective salvage therapy with minimal impact on quality of life.
脉冲电场（PEF）消融是一种新兴的非热消融设备，此前已用于肺癌、肝癌和肉瘤的治疗。我们报告一例前列腺癌放疗后复发并接受PEF消融治疗的病例。在经会阴引导下，将靶向PEF应用于先前活检和PSMA检查中发现问题的区域。随访发现，患者的前列腺特异性抗原（PSA）水平显著下降，后续PSMA检查结果恢复正常。患者未出现明显副作用，尿失禁和性功能得以保留。这些结果凸显了PEF消融作为一种安全有效的挽救治疗方法的潜力，对生活质量的影响极小。
