Yang Shao, Luo Wei, Sun Yawei, Wang Shan
Graduate School, Shandong First Medical University, Jinan, Shandong, China.
Department of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Endocrinol (Lausanne). 2025 Apr 9;16:1576333. doi: 10.3389/fendo.2025.1576333. eCollection 2025.
Delayed childbearing has led to a continuous rise in the incidence of infertility because of social development and the evolving roles of women. Assisted reproductive technology (ART) has provided new opportunities for infertility treatment, such as the application of growth hormone (GH). GH regulates ovarian function through multiple pathways, improving follicular development and hormone secretion. However, traditional GH therapy is limited by issues such as low bioavailability and insufficient delivery efficiency. In recent years, drug delivery systems based on novel biomaterials have provided breakthrough solutions for the innovative application of GH in ART. This review summarizes the mechanisms by which GH affects ovarian endocrine function and focuses on the cutting-edge advancements in GH delivery systems with examination of the innovative applications of composite biomaterials in enhancing the therapeutic efficacy of GH. By analyzing the pharmacokinetic properties of novel formulations, the safety and long-term efficacy of their clinical applications can be evaluated. GH delivery systems based on novel biomaterials considerably improve the bioavailability and targeting of GH and could lead to innovative therapeutic strategies for preventing and treating ovarian dysfunction and related diseases. By integrating multidisciplinary research findings, we provide new insights into the field of reproductive medicine that could lead to theoretical and practical importance for promoting the innovative development of ART.
由于社会发展和女性角色的演变，晚育导致不孕症发病率持续上升。辅助生殖技术（ART）为不孕症治疗提供了新的机遇，例如生长激素（GH）的应用。GH通过多种途径调节卵巢功能，改善卵泡发育和激素分泌。然而，传统的GH治疗受到生物利用度低和递送效率不足等问题的限制。近年来，基于新型生物材料的药物递送系统为GH在ART中的创新应用提供了突破性解决方案。本文综述了GH影响卵巢内分泌功能的机制，重点介绍了GH递送系统的前沿进展，并探讨了复合生物材料在提高GH治疗效果方面的创新应用。通过分析新型制剂的药代动力学特性，可以评估其临床应用的安全性和长期疗效。基于新型生物材料的GH递送系统显著提高了GH的生物利用度和靶向性，并可能为预防和治疗卵巢功能障碍及相关疾病带来创新的治疗策略。通过整合多学科研究成果，我们为生殖医学领域提供了新的见解，这可能对促进ART的创新发展具有理论和实际意义。
