Higashino Naoko, Ishihara Takayuki, Tsujimura Takuya, Hata Yosuke, Nakao Sho, Kusuda Masaya, Mano Toshiaki
Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan.
J Cardiol Cases. 2024 Dec 6;31(2):46-48. doi: 10.1016/j.jccase.2024.11.002. eCollection 2025 Feb.
A 72-year-old woman undergoing hemodialysis presented with effort angina pectoris due to severe stenosis with calcified nodules in the right coronary artery. Percutaneous coronary intervention was performed using an excimer laser coronary angioplasty and an ultrathin-strut covered stent (CS) was implanted due to coronary perforation. An additional durable-polymer everolimus-eluting stent (DP-EES) was implanted because of protrusions in the proximal edge of the CS. However, late stent thrombosis occurred six months after ultrathin-strut covered stent implantation for a calcified nodule. After thrombus aspiration, intravascular imaging analyses revealed that the struts within the CS were fully covered with thick neointimal hyperplasia. In contrast, half of the struts in the DP-EES were uncovered and some struts were malapposed. In this case, we speculated that the cause of the current late stent thrombosis was dispersion of the thrombi formed at the uncovered with malapposed sites in the DP-EES into a severe stenosis caused by neointimal hyperplasia in the CS. Neointimal hyperplasia occurs at the edge of the CS, a CS should be implanted locating its edge on the site with less plaque.
•To evaluate the mechanism of late stent thrombosis after ultrathin strut-covered stent implantation for lesions with calcified nodules.•To discuss the optimal covered stent placement locating its edge on the site with less plaque.•To recognize that introduction of an ultrathin-strut covered stent for lesions with calcified nodules requires careful consideration.
一名接受血液透析的72岁女性因右冠状动脉严重狭窄伴钙化结节出现劳力性心绞痛。采用准分子激光冠状动脉成形术进行经皮冠状动脉介入治疗,并因冠状动脉穿孔植入了超薄支撑覆膜支架(CS)。由于CS近端边缘有突出,又植入了一枚耐用聚合物依维莫司洗脱支架(DP-EES)。然而,在为钙化结节植入超薄支撑覆膜支架六个月后发生了晚期支架血栓形成。血栓抽吸后,血管内成像分析显示CS内的支架完全被厚厚的新生内膜增生覆盖。相比之下,DP-EES中有一半的支架未被覆盖,且一些支架贴靠不良。在这种情况下,我们推测当前晚期支架血栓形成的原因是在DP-EES中未被覆盖且贴靠不良部位形成的血栓扩散到由CS内新生内膜增生导致的严重狭窄处。新生内膜增生发生在CS边缘,应将CS边缘置于斑块较少的部位植入。
•评估为有钙化结节的病变植入超薄支撑覆膜支架后晚期支架血栓形成的机制。•讨论将覆膜支架边缘置于斑块较少部位的最佳植入方法。•认识到为有钙化结节的病变引入超薄支撑覆膜支架需要谨慎考虑。