1 Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan.
2 Division of Laboratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan.
J Endovasc Ther. 2017 Oct;24(5):746-750. doi: 10.1177/1526602817719881. Epub 2017 Jul 10.
To report histological examination of a Viabahn stent-graft implanted in the superficial femoral artery (SFA) for nearly 2 years.
A 78-year-old man with peripheral artery disease was treated successfully with a 6.0×250-mm Viabahn self-expanding stent-graft in the right SFA, relieving his lower limb claudication. The patient died suddenly due to acute myocardial infarction 23 months later. Histological evaluation of the stent-graft implantation site revealed moderate neointimal proliferation at both proximal and distal edges of the device. In the middle part of the stent, significant macrophages and multinucleated foreign body giant cells had accumulated, although the stent was entirely patent. Furthermore, no endothelial cell coverage was found.
Judging from these features, it might be necessary to continue dual antiplatelet therapy after stent-graft implantation over the long term to prevent thrombosis and subsequent restenosis or reocclusion.
报告在股浅动脉（SFA）中植入 Viabahn 支架移植物近 2 年后的组织学检查结果。
一名 78 岁男性因外周动脉疾病，在右侧 SFA 中成功接受了 6.0×250mm 的 Viabahn 自膨式支架移植物治疗，缓解了下肢跛行。23 个月后，该患者因急性心肌梗死突然死亡。支架植入部位的组织学评估显示，装置的近端和远端边缘均有中度新生内膜增殖。在支架的中部，大量巨噬细胞和多核异物巨细胞聚集，尽管支架完全通畅。此外，没有发现内皮细胞覆盖。
根据这些特征，支架植入后可能需要长期继续双联抗血小板治疗，以预防血栓形成以及随后的再狭窄或再闭塞。
