Leow C J, Piller K R
Department of Biological Sciences, Southeastern Louisiana University, Hammond, LA 70402, USA.
Integr Org Biol. 2025 Apr 17;7(1):obaf016. doi: 10.1093/iob/obaf016. eCollection 2025.
The African turquoise killifish is a powerful model organism in aging research. Within the family Nothobranchiidae, a wide range of lifespan is observed in annual, semi-annual, and non-annual life histories. In this study, we examined the brain transcriptomic signatures of adult nothobranchids across life history variations. Our results show that the brain gene expression profiles exhibit strong life history signatures compared to the liver tissue. Semi-annual species shows upregulation in cell division and mitosis compared to non-annual species. We identified genes related to neurogenesis such as , , and that show downregulation in the short-lived annual species compared to other life histories. The Notch signaling pathway is enriched in the non-annual species suggesting the importance of this pathway in longer-lived killifish. Our study demonstrates that other non-model nothobranchids can be used as comparative species to in the study of aging, neurogenesis, and life history.
非洲 turquoise 鳉是衰老研究中一种强大的模式生物。在假鳃鳉科中，一年生、半年生和非一年生的生活史呈现出广泛的寿命范围。在本研究中，我们研究了不同生活史的成年假鳃鳉的脑转录组特征。我们的结果表明，与肝脏组织相比，脑基因表达谱呈现出强烈的生活史特征。与非一年生物种相比，半年生物种在细胞分裂和有丝分裂方面表现出上调。我们鉴定出了与神经发生相关的基因，如 、 和 ，这些基因在短命的一年生物种中与其他生活史相比呈现出下调。Notch 信号通路在非一年生物种中富集，表明该通路在寿命更长的鳉鱼中的重要性。我们的研究表明，其他非模式假鳃鳉可以用作比较物种，用于衰老、神经发生和生活史的研究。
