在药物研发早期发现去甲丙咪嗪羟化能力差的个体中CGP 15 210 G的药代动力学改变。
Discovery of altered pharmacokinetics of CGP 15 210 G in poor hydroxylators of debrisoquine during early drug development.
作者信息
Gleiter C H, Aichele G, Nilsson E, Hengen N, Antonin K H, Bieck P R
出版信息
Br J Clin Pharmacol. 1985 Jul;20(1):81-4. doi: 10.1111/j.1365-2125.1985.tb02802.x.
Abstract
The pharmacokinetics of CGP 15 210 G, a new 5-HT uptake inhibitor in poor and extensive metabolisers of debrisoquine, give indirect evidence of an association between its metabolism and polymorphic hydroxylation of the debrisoquine type.
摘要
CGP 15 210 G是一种新型5-羟色胺摄取抑制剂，在异喹胍代谢能力差和代谢能力强的人群中的药代动力学，间接证明了其代谢与异喹胍型多态性羟基化之间存在关联。
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本文引用的文献
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A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.对英国白人人群中异喹胍氧化遗传多态性的家系及群体研究。
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Protecting poor metabolizers, a group at high risk of adverse drug reactions.保护代谢缓慢者，这是一组药物不良反应高风险人群。
Lancet. 1983 Jun 18;1(8338):1388. doi: 10.1016/s0140-6736(83)92172-4.
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Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection.采用气相色谱-火焰离子化和氮选择性检测法测定生物流体中的异喹胍及其4-羟基代谢物。
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Polymorphic hydroxylation of Debrisoquine in man.人对异喹胍的多态性羟基化作用。
Lancet. 1977 Sep 17;2(8038):584-6. doi: 10.1016/s0140-6736(77)91430-1.
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