Sedgwick A D, Moore A R, Al-Duaij A Y, Edwards J C, Willoughby D A
Br J Exp Pathol. 1985 Aug;66(4):455-64.
We have developed a model of prolonged immunological inflammation in the rat which has a structural resemblance to the synovial changes in rheumatoid arthritis. Pertussis vaccine was injected into 6-day-old subcutaneous air pouches in animals previously sensitized with pertussis vaccine. The resulting inflammatory response persisted up to 30 days. Examination of exudates showed a wave of polymorphonuclear leucocytes over a 13-day period followed by a mononuclear cell predominance up to 30 days. Histologically, an early polymorphonuclear cell infiltration was followed by the formation of a lining layer of large eosinophilic mononuclear cells, together with deep collections of lymphocytes and plasma cells. Concentrations of the acute-phase reactant alpha 1-glycoprotein, in both serum and exudate, peaked at 3 days. This suggests that the local production of interleukin I in this type of tissue reaction is more closely related to the acute inflammatory phase than to more chronic interactions between monocyte derived cells and lymphocytes.
我们已经建立了一种大鼠长期免疫炎症模型，其在结构上与类风湿性关节炎的滑膜变化相似。将百日咳疫苗注射到先前用百日咳疫苗致敏的6日龄动物的皮下气袋中。由此产生的炎症反应持续长达30天。对渗出物的检查显示，在13天的时间里有一波多形核白细胞，随后直到30天单核细胞占主导。组织学上，早期多形核细胞浸润之后是由大的嗜酸性单核细胞形成的衬里层，以及淋巴细胞和浆细胞的深部聚集。血清和渗出物中急性期反应物α1-糖蛋白的浓度在第3天达到峰值。这表明在这种类型的组织反应中白细胞介素I的局部产生与急性炎症期的关系比与单核细胞衍生细胞和淋巴细胞之间更慢性的相互作用更为密切。
