Seri I, Tulassay T, Kiszel J, Ruppert F, Sulyok E, Ertl T, Bódis J, Csömör S
Biol Neonate. 1985;47(6):317-22. doi: 10.1159/000242134.
The effect of low-dose (2-4 micrograms/kg/min) and long-term (greater than or equal to 46 h) dopamine infusion on serum prolactin and thyrotropin concentrations was investigated in 8 preterm infants with hyaline membrane disease. Dopamine was administered for systemic hypotension and/or for impending renal failure. Serum prolactin decreased from 1,314.5 +/- 422.7 microU/ml to 489.9 +/- 464.1 microU/ml (p less than 0.005), while serum thyrotropin fell from 3.77 +/- 2.27 microU/ml to 1.01 +/- 0.25 microU/ml (p less than 0.025) during dopamine infusion. Our data indicate that exogenous dopamine exerts an inhibitory effect on the secretion of prolactin and thyrotropin even in the sick preterm neonate. The role of prolactin in fetal lung maturation and in regulation of the neonatal tissue water stores is discussed. The results of the present study are also useful in explaining the renal effects of long-term low-dose dopamine infusion in the sick preterm infant.
在8例患有透明膜病的早产儿中，研究了低剂量（2 - 4微克/千克/分钟）和长期（大于或等于46小时）输注多巴胺对血清催乳素和促甲状腺激素浓度的影响。多巴胺用于治疗系统性低血压和/或即将发生的肾衰竭。在输注多巴胺期间，血清催乳素从1314.5±422.7微单位/毫升降至489.9±464.1微单位/毫升（p<0.005），而血清促甲状腺激素从3.77±2.27微单位/毫升降至1.01±0.25微单位/毫升（p<0.025）。我们的数据表明，外源性多巴胺即使在患病的早产新生儿中也对催乳素和促甲状腺激素的分泌具有抑制作用。讨论了催乳素在胎儿肺成熟和新生儿组织水分储存调节中的作用。本研究结果也有助于解释长期低剂量多巴胺输注对患病早产儿肾脏的影响。
