Kerr Tyler A, Nelson Yessica A, Bernier Nicholas A, Spokoyny Alexander M
Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States.
Inorg Chem. 2025 May 12;64(18):8845-8850. doi: 10.1021/acs.inorgchem.5c00469. Epub 2025 Apr 24.
Advancements in thermal neutron generation technologies within clinical environments have led to a renewed interest in developing boron-containing compounds for boron neutron capture therapy (BNCT). Previous syntheses of several key boron cluster-based therapeutics with clinical relevance are low-yielding and have complicated workup procedures. Using electrolytic methods, we report the oxidation of pseudohalides, [SCN] and [SeCN], to synthesize pseudohalogenated products, BHYCN (Y = S or Se). Further, these compounds can be reduced to their respective thiol or selenol, [BHSH] (BSH) or [BHSeH] (BSeH), which are exceedingly nucleophilic and able to form zwitterionic sulfonium and selenonium compounds using alkyl-based electrophiles. The newly reported preparation of BSH and BSeH provides an efficient and convenient route to the preparation of key chalcogenated boron cluster building blocks for the biomedical and materials science communities.
临床环境中热中子产生技术的进步引发了人们对开发用于硼中子俘获疗法（BNCT）的含硼化合物的新兴趣。先前合成的几种具有临床相关性的关键硼簇基治疗剂产率低且后处理程序复杂。我们报道了使用电解方法将拟卤化物[SCN]和[SeCN]氧化，以合成拟卤代产物BHYCN（Y = S或Se）。此外，这些化合物可以还原为各自的硫醇或硒醇，即[BHSH]（BSH）或[BHSeH]（BSeH），它们具有极强的亲核性，并且能够使用基于烷基的亲电试剂形成两性离子锍和硒鎓化合物。新报道的BSH和BSeH的制备为生物医学和材料科学界制备关键的硫属元素化硼簇结构单元提供了一条高效便捷的途径。
