Taniguchi Masashi, Ikezoe Tome, Tsuboyama Tadao, Ito Hiromu, Matsuda Shuichi, Matsuda Fumihiko, Ichihashi Noriaki
Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-Ku, Kyoto 606-8507, Japan.
Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-Ku, Kyoto 606-8507, Japan; Faculty of Rehabilitation, Kansai Medical University, 18-89 Uyama Higashimachi, Hirakata, Osaka 573-1136, Japan.
Gait Posture. 2025 Jul;120:211-216. doi: 10.1016/j.gaitpost.2025.04.013. Epub 2025 Apr 14.
Gait characteristics of spatiotemporal parameters of knee osteoarthritis (OA) using large sample of patients with various radiographic severities and asymmetry have not been studied previously.
This study aimed to determine the disease-specific gait characteristics of knee OA and assess the spatiotemporal gait parameters associated with functional disability.
The data was extracted from the Nagahama study and included 1591 participants aged ≥ 60 years, who underwent knee radiography and gait analysis. Of these, 998 (62.7 %) were assigned to healthy control group and 593 (37.3 %) to knee OA group. Gait speed, cadence, stride length, step length asymmetry, and step-time variability were measured using wearable inertial sensor. The Knee Scoring System (KSS) was used to assess functional disability. Logistic regression analysis was performed, with group variables as dependent variables and gait parameters as independent variables. In knee OA group, multiple regression analysis was performed with KSS score as dependent variable and gait parameters as independent variables after adjusting for potential confounders.
Step-time variability was associated with knee OA (adjusted odds ratio [OR], 1.08; 95 % confidence interval [CI], 1.00-1.15; p = 0.037). Lower gait speed (Beta [B]=13.60; 95 %CI, 4.41-22.80; p = 0.004) and higher step-time variability (B=-0.82; 95 %CI, -1.40 to -0.24; p = 0.005) were associated with a decrease in KSS score in knee OA.
These findings suggest that higher step-time variability is a specific gait characteristic of knee OA and is a negative factor associated with functional disabilities. The assessment of step-time variability is a useful indicator for screening abnormal gait patterns in knee OA.
此前尚未对大量不同放射学严重程度和不对称性的膝关节骨关节炎（OA）患者的时空参数步态特征进行研究。
本研究旨在确定膝关节OA特定疾病的步态特征，并评估与功能残疾相关的时空步态参数。
数据取自长滨研究，包括1591名年龄≥60岁的参与者，他们接受了膝关节X线摄影和步态分析。其中，998人（62.7%）被分配到健康对照组，593人（37.3%）被分配到膝关节OA组。使用可穿戴惯性传感器测量步态速度、步频、步长、步长不对称性和步时变异性。采用膝关节评分系统（KSS）评估功能残疾情况。进行逻辑回归分析，以组变量为因变量，步态参数为自变量。在膝关节OA组中，在调整潜在混杂因素后，以KSS评分为因变量，步态参数为自变量进行多元回归分析。
步时变异性与膝关节OA相关（调整后的优势比[OR]，1.08；95%置信区间[CI]，1.00 - 1.15；p = 0.037）。较低的步态速度（β[B]=13.60；95%CI，4.41 - 22.80；p = 0.004）和较高的步时变异性（B = -0.82；95%CI，-1.40至-0.24；p = 0.005）与膝关节OA患者KSS评分降低相关。
这些发现表明，较高的步时变异性是膝关节OA的一种特定步态特征，并且是与功能残疾相关的负面因素。步时变异性的评估是筛查膝关节OA异常步态模式的有用指标。
