Tordjman Lea, Mashoudy Kayla D, Czarnowicki Tali
University of Miami Miller School of Medicine, Miami, Fla.
Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla.
J Allergy Clin Immunol. 2025 Apr 22. doi: 10.1016/j.jaci.2025.04.016.
Emerging evidence reveals significant epidemiologic, genetic, and immunologic connections between atopic dermatitis, vitiligo, and alopecia areata, challenging previously established notions of their distinct pathogenic and molecular signatures. Exploring these commonalities not only enhances our understanding of each disease's pathogenesis, but also supports the development of unified treatment strategies for these frequently co-occurring disorders. This review examines key immune players shared across the 3 conditions, including cytokines, immune cells, and signaling pathways. Building on these insights, we also evaluate a range of therapeutic options-ranging from treatments approved by the Food and Drug Administration to those currently in clinical trials-alongside proposed future therapeutic targets. This comprehensive approach aims to advance our management of these interconnected autoimmune and inflammatory disorders with greater precision.
新出现的证据揭示了特应性皮炎、白癜风和斑秃之间在流行病学、遗传学和免疫学方面的显著联系，挑战了此前关于它们独特致病机制和分子特征的既定观念。探索这些共性不仅能增进我们对每种疾病发病机制的理解，还支持为这些经常同时出现的疾病制定统一的治疗策略。本综述探讨了这三种疾病共有的关键免疫因素，包括细胞因子、免疫细胞和信号通路。基于这些见解，我们还评估了一系列治疗选择，从美国食品药品监督管理局批准的治疗方法到目前正在进行临床试验的方法，以及未来提议的治疗靶点。这种全面的方法旨在更精确地推进我们对这些相互关联的自身免疫性和炎症性疾病的管理。
