地尔硫䓬对去甲肾上腺素释放的影响。
The effect of diltiazem on noradrenaline release.
作者信息
Wolchinsky C, Zsotér T T
出版信息
Br J Pharmacol. 1985 Jun;85(2):387-93. doi: 10.1111/j.1476-5381.1985.tb08873.x.
Abstract
The effects of diltiazem in rat tail arteries and guinea-pig vasa deferentia have been investigated. Superfusion of the rat tail artery with diltiazem (10(-6) - 10(-4) M) resulted in a dose-related increase in 3H-overflow (P less than 0.001) both in Wistar Kyoto (WKY) and in spontaneously hypertensive (SHR) rats. Release of 3H by transmural stimulation (1 Hz, 2 ms, 10 V) was also much greater in vessels perfused with diltiazem; this effect was dose-dependent. Diltiazem did not significantly alter the proportion of noradrenaline and its metabolites in 3H-overflow, as analysed by column chromatography. In the vasa deferentia of guinea-pigs, diltiazem (10(-9) - 10(-5) M) increased spontaneous 3H-release. The results indicate that diltiazem acts on sympathetic nerves and causes the release of noradrenaline.
摘要
已对地尔硫䓬在大鼠尾动脉和豚鼠输精管中的作用进行了研究。用地尔硫䓬（10⁻⁶ - 10⁻⁴ M）对大鼠尾动脉进行超灌注，在Wistar Kyoto（WKY）大鼠和自发性高血压（SHR）大鼠中均导致³H溢出呈剂量相关增加（P < 0.001）。在用地尔硫䓬灌注的血管中，经壁刺激（1 Hz，2 ms，10 V）引起的³H释放也显著增加；这种效应呈剂量依赖性。通过柱色谱分析，地尔硫䓬并未显著改变³H溢出中去甲肾上腺素及其代谢产物的比例。在豚鼠输精管中，地尔硫䓬（10⁻⁹ - 10⁻⁵ M）增加了³H的自发性释放。结果表明，地尔硫䓬作用于交感神经并导致去甲肾上腺素释放。
相似文献
1
The effect of diltiazem on noradrenaline release.地尔硫䓬对去甲肾上腺素释放的影响。
Br J Pharmacol. 1985 Jun;85(2):387-93. doi: 10.1111/j.1476-5381.1985.tb08873.x.
2
The effect of nifedipine on norepinephrine release.硝苯地平对去甲肾上腺素释放的影响。
Arch Int Pharmacodyn Ther. 1986 Mar;280(1):32-44.
3
Preferential antagonism by diltiazem of alpha 2-adrenoceptor mediated vasoconstrictor responses in perfused tail arteries of spontaneous hypertensive rats.地尔硫䓬对自发性高血压大鼠灌流尾动脉中α2 -肾上腺素能受体介导的血管收缩反应的选择性拮抗作用。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Feb;328(4):388-95. doi: 10.1007/BF00692906.
4
Effects of verapamil on [3H]norepinephrine release.
J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1060-6.
5
Norepinephrine release in arteries of spontaneously hypertensive rats.
Clin Exp Hypertens A. 1982;4(3):431-44. doi: 10.3109/10641968209060753.
6
Enhanced neuroinhibitory effect of diltiazem in blood vessels of spontaneously hypertensive rats.
Am J Hypertens. 1990 Jul;3(7):555-9. doi: 10.1093/ajh/3.7.555.
7
Vascular smooth muscle responses in normo- and hypertensive rats to sympathetic nerve stimulation and putative transmitters.正常血压和高血压大鼠对交感神经刺激及假定递质的血管平滑肌反应。
J Auton Pharmacol. 1989 Feb;9(1):23-34. doi: 10.1111/j.1474-8673.1989.tb00193.x.
8
Effect of blockade of noradrenaline re-uptake on evoked tritium overflow from mouse vasa deferentia and rat cortex slices.去甲肾上腺素再摄取阻断对小鼠输精管和大鼠皮层切片诱发的氚溢出的影响。
Br J Pharmacol. 1990 Nov;101(3):762-8. doi: 10.1111/j.1476-5381.1990.tb14153.x.
9
Release of noradrenaline and dopamine by nerve stimulation in the guinea-pig and rat vas deferens.通过神经刺激在豚鼠和大鼠输精管中释放去甲肾上腺素和多巴胺。
Br J Pharmacol. 1984 Mar;81(3):563-9. doi: 10.1111/j.1476-5381.1984.tb10110.x.
引用本文的文献
1
Differential effects of Ca antagonists on the noradrenaline release and contraction evoked by nerve stimulation in the presence of 4-aminopyridine.在存在4-氨基吡啶的情况下，钙拮抗剂对神经刺激诱发的去甲肾上腺素释放和收缩的不同作用。
Br J Pharmacol. 1987 Jan;90(1):191-201. doi: 10.1111/j.1476-5381.1987.tb16840.x.
2
Effects of calcium channel antagonists on action potential conduction and transmitter release in the guinea-pig vas deferens.钙通道拮抗剂对豚鼠输精管动作电位传导及递质释放的影响。
Br J Pharmacol. 1986 Sep;89(1):235-44. doi: 10.1111/j.1476-5381.1986.tb11140.x.
3
Effects of pinacidil on the sympatho-adrenal system in dogs.匹那地尔对犬交感-肾上腺系统的影响。
Br J Pharmacol. 1989 Aug;97(4):1019-26. doi: 10.1111/j.1476-5381.1989.tb12557.x.
4
Differential effect of omega-conotoxin on release of the adrenergic transmitter and the vasoconstrictor response to noradrenaline in the rat isolated kidney.ω-芋螺毒素对大鼠离体肾脏中肾上腺素能递质释放及去甲肾上腺素血管收缩反应的差异作用。
Br J Pharmacol. 1988 Jun;94(2):355-62. doi: 10.1111/j.1476-5381.1988.tb11537.x.
5
Effects of nifedipine versus hydralazine on sympathetic activity and cardiac function in patients with hypertension persisting on diuretic plus beta-blocker therapy.
Cardiovasc Drugs Ther. 1990 Apr;4(2):499-504. doi: 10.1007/BF01857760.
6
Psychopharmacological properties of calcium channel inhibitors.钙通道抑制剂的精神药理学特性。
Psychopharmacology (Berl). 1992;109(1-2):12-29. doi: 10.1007/BF02245476.
本文引用的文献
1
Development of a strain of spontaneously hypertensive rats.一种自发性高血压大鼠品系的培育
Jpn Circ J. 1963 Mar;27:282-93. doi: 10.1253/jcj.27.282.
2
Adrenergic activity in arteries of spontaneously hypertensive rats.自发性高血压大鼠动脉中的肾上腺素能活性。
Can J Physiol Pharmacol. 1981 Oct;59(10):1104-7. doi: 10.1139/y81-169.
3
Norepinephrine release in arteries of spontaneously hypertensive rats.
Clin Exp Hypertens A. 1982;4(3):431-44. doi: 10.3109/10641968209060753.
4
Short- and long-term efficacy of high-dose oral diltiazem for angina due to coronary artery disease: a placebo-controlled, randomized, double-blind crossover study.大剂量口服地尔硫䓬治疗冠状动脉疾病所致心绞痛的短期和长期疗效：一项安慰剂对照、随机、双盲交叉研究。
Circulation. 1983 Jul;68(1):139-47. doi: 10.1161/01.cir.68.1.139.
5
A reserpine-like action of verapamil on cardiac sympathetic nerves.维拉帕米对心脏交感神经的利血平样作用。
Eur J Pharmacol. 1984 Jan 13;97(1-2):156-8. doi: 10.1016/0014-2999(84)90526-0.
6
Calcium antagonists. Pharmacokinetic properties.钙拮抗剂。药代动力学特性。
Drugs. 1983 Feb;25(2):113-24. doi: 10.2165/00003495-198325020-00002.
7
Presynaptic alpha 2-adrenoceptor antagonism by verapamil but not by diltiazem in rabbit hypothalamic slices.维拉帕米而非地尔硫䓬对兔下丘脑切片突触前α2-肾上腺素能受体的拮抗作用。
Br J Pharmacol. 1983 Mar;78(3):571-7. doi: 10.1111/j.1476-5381.1983.tb08817.x.
8
Calcium antagonists. Pharmacodynamic effects and mechanism of action.钙拮抗剂。药效学作用及作用机制。
Drugs. 1983 Feb;25(2):93-112. doi: 10.2165/00003495-198325020-00001.
9
Effects of verapamil on [3H]norepinephrine release.
J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1060-6.
10
[Differences between tyramine and dimethylphenylpiperazine in the Ca++-dependency and in the temporary course of noradrenaline release from the isolated rabbit heart].[酪胺与二甲基苯基哌嗪在钙离子依赖性以及从离体兔心脏释放去甲肾上腺素的时间过程方面的差异]
Experientia. 1967 Nov 15;23(11):933-4. doi: 10.1007/BF02136230.
Zotero 插件