地尔硫䓬对去甲肾上腺素释放的影响。
The effect of diltiazem on noradrenaline release.
作者信息
Wolchinsky C, Zsotér T T
出版信息
Br J Pharmacol. 1985 Jun;85(2):387-93. doi: 10.1111/j.1476-5381.1985.tb08873.x.
The effects of diltiazem in rat tail arteries and guinea-pig vasa deferentia have been investigated. Superfusion of the rat tail artery with diltiazem (10(-6) - 10(-4) M) resulted in a dose-related increase in 3H-overflow (P less than 0.001) both in Wistar Kyoto (WKY) and in spontaneously hypertensive (SHR) rats. Release of 3H by transmural stimulation (1 Hz, 2 ms, 10 V) was also much greater in vessels perfused with diltiazem; this effect was dose-dependent. Diltiazem did not significantly alter the proportion of noradrenaline and its metabolites in 3H-overflow, as analysed by column chromatography. In the vasa deferentia of guinea-pigs, diltiazem (10(-9) - 10(-5) M) increased spontaneous 3H-release. The results indicate that diltiazem acts on sympathetic nerves and causes the release of noradrenaline.
已对地尔硫䓬在大鼠尾动脉和豚鼠输精管中的作用进行了研究。用地尔硫䓬（10⁻⁶ - 10⁻⁴ M）对大鼠尾动脉进行超灌注，在Wistar Kyoto（WKY）大鼠和自发性高血压（SHR）大鼠中均导致³H溢出呈剂量相关增加（P < 0.001）。在用地尔硫䓬灌注的血管中，经壁刺激（1 Hz，2 ms，10 V）引起的³H释放也显著增加；这种效应呈剂量依赖性。通过柱色谱分析，地尔硫䓬并未显著改变³H溢出中去甲肾上腺素及其代谢产物的比例。在豚鼠输精管中，地尔硫䓬（10⁻⁹ - 10⁻⁵ M）增加了³H的自发性释放。结果表明，地尔硫䓬作用于交感神经并导致去甲肾上腺素释放。
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